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Serum zinc deficiency could be associated with dementia conversion in Parkinson's disease
Association between heavy metals and Parkinson's disease (PD) is well noted, but studies regarding heavy metal levels and non-motor symptoms of PD, such as PD's dementia (PD-D), are lacking. In this retrospective cohort study, we compared five serum heavy metal levels (Zn, Cu, Pb, Hg, and...
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| Published in: | Frontiers in aging neuroscience 2023-04, Vol.15, p.1132907-1132907 |
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| description | Association between heavy metals and Parkinson's disease (PD) is well noted, but studies regarding heavy metal levels and non-motor symptoms of PD, such as PD's dementia (PD-D), are lacking.
In this retrospective cohort study, we compared five serum heavy metal levels (Zn, Cu, Pb, Hg, and Mn) of newly diagnosed PD patients (
= 124). Among 124 patients, 40 patients were later converted to Parkinson's disease dementia (PD-D), and 84 patients remained without dementia during the follow-up time. We collected clinical parameters of PD and conducted correlation analysis with heavy metal levels. PD-D conversion time was defined as the initiation time of cholinesterase inhibitors. Cox proportional hazard models were used to identify factors associated with dementia conversion in PD subjects.
Zn deficiency was significant in the PD-D group than in the PD without dementia group (87.53 ± 13.20 vs. 74.91 ± 14.43,
|
| doi_str_mv | 10.3389/fnagi.2023.1132907 |
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| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_56f3c77ec2a54cc1ae5e5861da6ea2d6</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_56f3c77ec2a54cc1ae5e5861da6ea2d6</doaj_id><sourcerecordid>2813889431</sourcerecordid><originalsourceid>FETCH-LOGICAL-c497t-5052c5cfbc2806c44fa0e63001f81f1c8c35b42bf76cb76396129bdc30696b0b3</originalsourceid><addsrcrecordid>eNpdkktv1DAUhS0EotW0f4AFisQCNjP1I3acFUIVj0qVQGpZsLKcm-uph8QudlLU_vp6OkPV4o0t-7tH9x4fQt4wuhJCtycu2LVfccrFijHBW9q8IIdMKbGshZIvn5wPyHHOG1qWEJRK_ZociIZppnh7SH5dYJrH6s4HqHp0HjwGuK0gzkNfdVjZnCN4O2Ff_fXTVWFGDJO3hQg3mLKPofKh-mHTbx9yDO9z1fuMNuMReeXskPF4vy_Izy-fL0-_Lc-_fz07_XS-hLptpqWkkoME1wHXVEFdO0tRlUaZ08wx0CBkV_PONQq6RolWMd52PQiqWtXRTizI2U63j3ZjrpMfbbo10XrzcBHT2tg0eRjQSOUENA0Ct7IGYBYlSq1YbxVa3qui9XGndT13I_ZQRk12eCb6_CX4K7OON4ZR1nBZDF6QD3uFFP_MmCcz-gw4DDZgnLPhmgmt21qwgr77D93EOYXildlawRta122h-I6CFHNO6B67YdRsk2AekmC2STD7JJSit0_neCz59-_iHuQTsHg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2806270449</pqid></control><display><type>article</type><title>Serum zinc deficiency could be associated with dementia conversion in Parkinson's disease</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Lee, Jieun ; Park, Suyeon ; Jang, Wooyoung</creator><creatorcontrib>Lee, Jieun ; Park, Suyeon ; Jang, Wooyoung</creatorcontrib><description>Association between heavy metals and Parkinson's disease (PD) is well noted, but studies regarding heavy metal levels and non-motor symptoms of PD, such as PD's dementia (PD-D), are lacking.
In this retrospective cohort study, we compared five serum heavy metal levels (Zn, Cu, Pb, Hg, and Mn) of newly diagnosed PD patients (
= 124). Among 124 patients, 40 patients were later converted to Parkinson's disease dementia (PD-D), and 84 patients remained without dementia during the follow-up time. We collected clinical parameters of PD and conducted correlation analysis with heavy metal levels. PD-D conversion time was defined as the initiation time of cholinesterase inhibitors. Cox proportional hazard models were used to identify factors associated with dementia conversion in PD subjects.
Zn deficiency was significant in the PD-D group than in the PD without dementia group (87.53 ± 13.20 vs. 74.91 ± 14.43,
< 0.01). Lower serum Zn level was significantly correlated with K-MMSE and LEDD at 3 months (
= -0.28,
< 0.01;
= 0.38,
< 0.01). Zn deficiency also contributed to a shorter time to dementia conversion (HR 0.953, 95% CI 0.919 to 0.988,
< 0.01).
This clinical study suggests that a low serum Zn level can be a risk factor for developing PD-D and could be used as a biological marker for PD-D conversion.</description><identifier>ISSN: 1663-4365</identifier><identifier>EISSN: 1663-4365</identifier><identifier>DOI: 10.3389/fnagi.2023.1132907</identifier><identifier>PMID: 37181629</identifier><language>eng</language><publisher>Switzerland: Frontiers Research Foundation</publisher><subject>Aging Neuroscience ; Alzheimer's disease ; Cholinesterase inhibitors ; Cognitive ability ; Copper ; Correlation analysis ; Dementia ; Dementia disorders ; heavy metal ; Heavy metals ; Laboratories ; Manganese ; Mass spectrometry ; Medical records ; Movement disorders ; Neurodegeneration ; Neurodegenerative diseases ; Nutrient deficiency ; Parkinson's disease ; Risk factors ; Scientific imaging ; Zinc</subject><ispartof>Frontiers in aging neuroscience, 2023-04, Vol.15, p.1132907-1132907</ispartof><rights>Copyright © 2023 Lee, Park and Jang.</rights><rights>2023. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2023 Lee, Park and Jang. 2023 Lee, Park and Jang</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-5052c5cfbc2806c44fa0e63001f81f1c8c35b42bf76cb76396129bdc30696b0b3</citedby><cites>FETCH-LOGICAL-c497t-5052c5cfbc2806c44fa0e63001f81f1c8c35b42bf76cb76396129bdc30696b0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2806270449/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2806270449?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37181629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Jieun</creatorcontrib><creatorcontrib>Park, Suyeon</creatorcontrib><creatorcontrib>Jang, Wooyoung</creatorcontrib><title>Serum zinc deficiency could be associated with dementia conversion in Parkinson's disease</title><title>Frontiers in aging neuroscience</title><addtitle>Front Aging Neurosci</addtitle><description>Association between heavy metals and Parkinson's disease (PD) is well noted, but studies regarding heavy metal levels and non-motor symptoms of PD, such as PD's dementia (PD-D), are lacking.
In this retrospective cohort study, we compared five serum heavy metal levels (Zn, Cu, Pb, Hg, and Mn) of newly diagnosed PD patients (
= 124). Among 124 patients, 40 patients were later converted to Parkinson's disease dementia (PD-D), and 84 patients remained without dementia during the follow-up time. We collected clinical parameters of PD and conducted correlation analysis with heavy metal levels. PD-D conversion time was defined as the initiation time of cholinesterase inhibitors. Cox proportional hazard models were used to identify factors associated with dementia conversion in PD subjects.
Zn deficiency was significant in the PD-D group than in the PD without dementia group (87.53 ± 13.20 vs. 74.91 ± 14.43,
< 0.01). Lower serum Zn level was significantly correlated with K-MMSE and LEDD at 3 months (
= -0.28,
< 0.01;
= 0.38,
< 0.01). Zn deficiency also contributed to a shorter time to dementia conversion (HR 0.953, 95% CI 0.919 to 0.988,
< 0.01).
This clinical study suggests that a low serum Zn level can be a risk factor for developing PD-D and could be used as a biological marker for PD-D conversion.</description><subject>Aging Neuroscience</subject><subject>Alzheimer's disease</subject><subject>Cholinesterase inhibitors</subject><subject>Cognitive ability</subject><subject>Copper</subject><subject>Correlation analysis</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>heavy metal</subject><subject>Heavy metals</subject><subject>Laboratories</subject><subject>Manganese</subject><subject>Mass spectrometry</subject><subject>Medical records</subject><subject>Movement disorders</subject><subject>Neurodegeneration</subject><subject>Neurodegenerative diseases</subject><subject>Nutrient deficiency</subject><subject>Parkinson's disease</subject><subject>Risk factors</subject><subject>Scientific imaging</subject><subject>Zinc</subject><issn>1663-4365</issn><issn>1663-4365</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkktv1DAUhS0EotW0f4AFisQCNjP1I3acFUIVj0qVQGpZsLKcm-uph8QudlLU_vp6OkPV4o0t-7tH9x4fQt4wuhJCtycu2LVfccrFijHBW9q8IIdMKbGshZIvn5wPyHHOG1qWEJRK_ZociIZppnh7SH5dYJrH6s4HqHp0HjwGuK0gzkNfdVjZnCN4O2Ff_fXTVWFGDJO3hQg3mLKPofKh-mHTbx9yDO9z1fuMNuMReeXskPF4vy_Izy-fL0-_Lc-_fz07_XS-hLptpqWkkoME1wHXVEFdO0tRlUaZ08wx0CBkV_PONQq6RolWMd52PQiqWtXRTizI2U63j3ZjrpMfbbo10XrzcBHT2tg0eRjQSOUENA0Ct7IGYBYlSq1YbxVa3qui9XGndT13I_ZQRk12eCb6_CX4K7OON4ZR1nBZDF6QD3uFFP_MmCcz-gw4DDZgnLPhmgmt21qwgr77D93EOYXildlawRta122h-I6CFHNO6B67YdRsk2AekmC2STD7JJSit0_neCz59-_iHuQTsHg</recordid><startdate>20230427</startdate><enddate>20230427</enddate><creator>Lee, Jieun</creator><creator>Park, Suyeon</creator><creator>Jang, Wooyoung</creator><general>Frontiers Research Foundation</general><general>Frontiers Media S.A</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20230427</creationdate><title>Serum zinc deficiency could be associated with dementia conversion in Parkinson's disease</title><author>Lee, Jieun ; Park, Suyeon ; Jang, Wooyoung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-5052c5cfbc2806c44fa0e63001f81f1c8c35b42bf76cb76396129bdc30696b0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aging Neuroscience</topic><topic>Alzheimer's disease</topic><topic>Cholinesterase inhibitors</topic><topic>Cognitive ability</topic><topic>Copper</topic><topic>Correlation analysis</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>heavy metal</topic><topic>Heavy metals</topic><topic>Laboratories</topic><topic>Manganese</topic><topic>Mass spectrometry</topic><topic>Medical records</topic><topic>Movement disorders</topic><topic>Neurodegeneration</topic><topic>Neurodegenerative diseases</topic><topic>Nutrient deficiency</topic><topic>Parkinson's disease</topic><topic>Risk factors</topic><topic>Scientific imaging</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Jieun</creatorcontrib><creatorcontrib>Park, Suyeon</creatorcontrib><creatorcontrib>Jang, Wooyoung</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Frontiers in aging neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Jieun</au><au>Park, Suyeon</au><au>Jang, Wooyoung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum zinc deficiency could be associated with dementia conversion in Parkinson's disease</atitle><jtitle>Frontiers in aging neuroscience</jtitle><addtitle>Front Aging Neurosci</addtitle><date>2023-04-27</date><risdate>2023</risdate><volume>15</volume><spage>1132907</spage><epage>1132907</epage><pages>1132907-1132907</pages><issn>1663-4365</issn><eissn>1663-4365</eissn><abstract>Association between heavy metals and Parkinson's disease (PD) is well noted, but studies regarding heavy metal levels and non-motor symptoms of PD, such as PD's dementia (PD-D), are lacking.
In this retrospective cohort study, we compared five serum heavy metal levels (Zn, Cu, Pb, Hg, and Mn) of newly diagnosed PD patients (
= 124). Among 124 patients, 40 patients were later converted to Parkinson's disease dementia (PD-D), and 84 patients remained without dementia during the follow-up time. We collected clinical parameters of PD and conducted correlation analysis with heavy metal levels. PD-D conversion time was defined as the initiation time of cholinesterase inhibitors. Cox proportional hazard models were used to identify factors associated with dementia conversion in PD subjects.
Zn deficiency was significant in the PD-D group than in the PD without dementia group (87.53 ± 13.20 vs. 74.91 ± 14.43,
< 0.01). Lower serum Zn level was significantly correlated with K-MMSE and LEDD at 3 months (
= -0.28,
< 0.01;
= 0.38,
< 0.01). Zn deficiency also contributed to a shorter time to dementia conversion (HR 0.953, 95% CI 0.919 to 0.988,
< 0.01).
This clinical study suggests that a low serum Zn level can be a risk factor for developing PD-D and could be used as a biological marker for PD-D conversion.</abstract><cop>Switzerland</cop><pub>Frontiers Research Foundation</pub><pmid>37181629</pmid><doi>10.3389/fnagi.2023.1132907</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Aging Neuroscience Alzheimer's disease Cholinesterase inhibitors Cognitive ability Copper Correlation analysis Dementia Dementia disorders heavy metal Heavy metals Laboratories Manganese Mass spectrometry Medical records Movement disorders Neurodegeneration Neurodegenerative diseases Nutrient deficiency Parkinson's disease Risk factors Scientific imaging Zinc |
| title | Serum zinc deficiency could be associated with dementia conversion in Parkinson's disease |
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