Changes in the incidence and prevalence of systemic lupus erythematosus between 1990 and 2020: an observational study using the Clinical Practice Research Datalink (CPRD)

ObjectiveTo obtain updated estimates on the incidence and prevalence of systemic lupus erythematosus (SLE) in the UK, over the period 1990–2020, using the Clinical Practice Research Datalink (CPRD).MethodsThis was a retrospective cohort study using the CPRD covering the period 1990–2020. A case asce...

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Bibliographic Details
Published in:Lupus science & medicine 2024-07, Vol.11 (2), p.e001213
Main Authors: Ellis, Jessica, McHugh, Neil, Pauling, John D, Bruce, Ian N, Charlton, Rachel, McGrogan, Anita, Skeoch, Sarah
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Algorithms
Archives & records
Arthritis
Clinical medicine
Codes
Data collection
Databases, Factual
Datasets
Disease
Epidemiology
Epidemiology and Outcomes
Estimates
Female
Humans
Incidence
Lupus
Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic - epidemiology
Male
Middle Aged
Original Research
Patients
Population
Practice research
Prevalence
Primary care
Retrospective Studies
Software
Trends
United Kingdom - epidemiology
Young Adult
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Summary:ObjectiveTo obtain updated estimates on the incidence and prevalence of systemic lupus erythematosus (SLE) in the UK, over the period 1990–2020, using the Clinical Practice Research Datalink (CPRD).MethodsThis was a retrospective cohort study using the CPRD covering the period 1990–2020. A case ascertainment algorithm was developed in line with best practice recommendations for observational research. Incidence was calculated per 100 000 person-years and point prevalence (at the mid-year point) calculated per 100 000. Results were stratified by sex.Results9443 SLE cases were identified. 5278 incident cases were identified (4538 women, 740 men). The overall incidence rate was 5.47 (95% CI 5.33 to 5.62) cases per 100 000 person-years. Incidence rates decreased slightly across the study period, which was more pronounced for women than men. Point prevalence increased over time, from 21.4 (95% CI 17.68 to 25.67) per 100 000 in 1990 to 107.14 (95% CI 103.26 to 111.12) per 100 000 in 2020.ConclusionsThe observed fivefold increase in prevalence of SLE over the last 30 years, in the context of a modest decline in incidence rate, may suggest improved outcomes in SLE and has important implications for healthcare service delivery and planning in the UK.
ISSN:2053-8790
2053-8790
DOI:10.1136/lupus-2024-001213