Zinc-modified phosphate-based glass micro-filler improves Candida albicans resistance of auto-polymerized acrylic resin without altering mechanical performance

Colonization of auto-polymerized acrylic resin by pathogenic Candida albicans is a common problem for denture users. In this study, zinc-modified phosphate-based glass was introduced into an auto-polymerized acrylic resin at concentrations of 3, 5, and 7 wt.%. The mechanical or physical properties (...

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Bibliographic Details
Published in:Scientific reports 2022-11, Vol.12 (1), p.19456-19456, Article 19456
Main Authors: Lee, Myung-Jin, Kim, Min-Ji, Mangal, Utkarsh, Seo, Ji-Young, Kwon, Jae-Sung, Choi, Sung-Hwan
Format: Article
Language:English
Subjects:
692/700/3032/3065/3070
692/700/3032/3155/3118
Acrylic Resins - pharmacology
Anti-Infective Agents
Antimicrobial agents
Candida albicans
Contact angle
Dentistry
Denture Bases
Dentures
Fungal infections
Humanities and Social Sciences
Materials Testing
Mechanical properties
multidisciplinary
Older people
Phosphates - pharmacology
Physical properties
Resins
Scanning electron microscopy
Science
Science (multidisciplinary)
Surface Properties
University colleges
Zinc
Zinc - pharmacology
Zinc oxides
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Summary:Colonization of auto-polymerized acrylic resin by pathogenic Candida albicans is a common problem for denture users. In this study, zinc-modified phosphate-based glass was introduced into an auto-polymerized acrylic resin at concentrations of 3, 5, and 7 wt.%. The mechanical or physical properties (flexural strength, elastic modulus, microhardness, and contact angle), surface morphology of the resultant materials, and the antimicrobial effect on C. albicans were investigated. There were no statistical differences in the mechanical properties between the control and the zinc-modified phosphate-based glass samples ( p  > 0.05); however, the number of C. albicans colony-forming units was significantly lower in the control group ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-24172-y