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The clinical meaning of lymphovascular invasion: preoperative predictors and postoperative implications in prostate cancer - a retrospective study
Lymphovascular invasion (LVI) is a pivotal histopathological parameter in prostate cancer (PCa), holding significant prognostic implications. Our study pursued a dual objective: firstly, to identify preoperative factors associated with LVI, aiming to unveil markers facilitating the recognition of pa...
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| Published in: | Frontiers in oncology 2024-05, Vol.14, p.1349536-1349536 |
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| creator | Karwacki, Jakub Łątkowska, Małgorzata Jarocki, Michał Jaworski, Arkadiusz Szuba, Przemysław Poterek, Adrian Lemiński, Artur Kaczmarek, Krystian Hałoń, Agnieszka Szydełko, Tomasz Małkiewicz, Bartosz |
| description | Lymphovascular invasion (LVI) is a pivotal histopathological parameter in prostate cancer (PCa), holding significant prognostic implications. Our study pursued a dual objective: firstly, to identify preoperative factors associated with LVI, aiming to unveil markers facilitating the recognition of patients prone to LVI during postoperative examination; and secondly, to assess postoperative outcomes correlated with LVI.
We retrospectively analyzed 861 nonmetastatic PCa patients who underwent radical prostatectomy (RP), investigating preoperative factors and postoperative outcomes. Surgical specimens were processed following established guidelines. Statistical analyses utilized non-parametric tests to assess the association between LVI and both pre- and postoperative factors. Furthermore, logistic regression analyses were utilized to develop models aimed at identifying the most significant predictors of LVI and pN1 status, respectively.
Numerous preoperative factors exhibited significant correlations with LVI, offering valuable clinical insights. Logistic regression identified magnetic resonance imaging (MRI)-based clinical tumor stage (cT) 3-4, biopsy Gleason Grading Group (GGG) 3-5, preoperative prostate specific antigen (PSA) ≥20 and percentage of positive biopsy cores (PPBC) ≥50% as the strongest preoperative predictors of LVI. Additionally, the study uncovered an association between LVI and postoperative outcomes, including postoperative PSA (
value |
| doi_str_mv | 10.3389/fonc.2024.1349536 |
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| fullrecord | <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_5a2afacdb8d246e299f8d6e65f5d14ae</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_5a2afacdb8d246e299f8d6e65f5d14ae</doaj_id><sourcerecordid>3057075744</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-e44df86fa6e5abddcfc34e17ec49891e826c7fce26a37379f319aa086b2ae93</originalsourceid><addsrcrecordid>eNpVkstuGyEUhkdVqyZK8wDdVCy7sTNchhm6qaqol0iRumgW3aFjONhEMzAFbMmv0Scujp00YcO5_d9B6G-a97Rdcj6oKxeDWbKWiSXlQnVcvmrOGeNioQT__fpZfNZc5nzf1iO7lrb8bXPGh16KbuDnzd-7DRIz-uANjGRCCD6sSXRk3E_zJu4gm-0IifhQQx_DJzInjDMmKH6Hh8R6U2LKBIIlc8zlf9NP81ixpcpyBdTh2oZS90EwmMiCAElYanVG86DIZWv375o3DsaMl6f7ovn17evd9Y_F7c_vN9dfbhdG0KEsUAjrBulAYgcra40zXCDt0Qg1KIoDk6Z3BpkE3vNeOU4VQDvIFQNU_KK5OVJthHs9Jz9B2usIXj8UYlprSMWbEXUHDBwYuxosExKZUm6wEmXnOksFYGV9PrLm7WpCazCUBOML6MtO8Bu9jjtNaasU62klfDwRUvyzxVz05LPBcYSAcZs1b7u-7bteiDpKj6OmflxO6J720FYfnKEPztAHZ-iTM6rmw_MHPikefcD_AfDFvBE</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3057075744</pqid></control><display><type>article</type><title>The clinical meaning of lymphovascular invasion: preoperative predictors and postoperative implications in prostate cancer - a retrospective study</title><source>PubMed Central</source><creator>Karwacki, Jakub ; Łątkowska, Małgorzata ; Jarocki, Michał ; Jaworski, Arkadiusz ; Szuba, Przemysław ; Poterek, Adrian ; Lemiński, Artur ; Kaczmarek, Krystian ; Hałoń, Agnieszka ; Szydełko, Tomasz ; Małkiewicz, Bartosz</creator><creatorcontrib>Karwacki, Jakub ; Łątkowska, Małgorzata ; Jarocki, Michał ; Jaworski, Arkadiusz ; Szuba, Przemysław ; Poterek, Adrian ; Lemiński, Artur ; Kaczmarek, Krystian ; Hałoń, Agnieszka ; Szydełko, Tomasz ; Małkiewicz, Bartosz</creatorcontrib><description><![CDATA[Lymphovascular invasion (LVI) is a pivotal histopathological parameter in prostate cancer (PCa), holding significant prognostic implications. Our study pursued a dual objective: firstly, to identify preoperative factors associated with LVI, aiming to unveil markers facilitating the recognition of patients prone to LVI during postoperative examination; and secondly, to assess postoperative outcomes correlated with LVI.
We retrospectively analyzed 861 nonmetastatic PCa patients who underwent radical prostatectomy (RP), investigating preoperative factors and postoperative outcomes. Surgical specimens were processed following established guidelines. Statistical analyses utilized non-parametric tests to assess the association between LVI and both pre- and postoperative factors. Furthermore, logistic regression analyses were utilized to develop models aimed at identifying the most significant predictors of LVI and pN1 status, respectively.
Numerous preoperative factors exhibited significant correlations with LVI, offering valuable clinical insights. Logistic regression identified magnetic resonance imaging (MRI)-based clinical tumor stage (cT) 3-4, biopsy Gleason Grading Group (GGG) 3-5, preoperative prostate specific antigen (PSA) ≥20 and percentage of positive biopsy cores (PPBC) ≥50% as the strongest preoperative predictors of LVI. Additionally, the study uncovered an association between LVI and postoperative outcomes, including postoperative PSA (
value <0.001), extracapsular extension (ECE) (<0.001), positive surgical margins (PSM) (<0.001), perineural invasion (PNI) (<0.001), pathological tumor stage (pT) (<0.001), pathological lymph node status (pN) (<0.001), postoperative GGG (<0.001), and operative time (0.023). Notably, the study revealed a novel and substantial association between LVI and an increased number of positive lymph nodes in pN+ patients in the univariate analysis (<0.001). Furthermore, we have found an association between LVI and pN1 status in the logistic regression analysis (odds ratio [OR] = 23.905;
0.001).
Our findings underscore the pivotal role of LVI in influencing the prognosis of prostate cancer (PCa). The study acknowledges the challenges associated with preoperative LVI assessment and emphasizes the need for future research to unravel the factors associated with this histopathological finding. Significantly, our research stands out as the first, to the best of our knowledge, to reveal the association between LVI and the number of positive lymph nodes in pN+ patients.]]></description><identifier>ISSN: 2234-943X</identifier><identifier>EISSN: 2234-943X</identifier><identifier>DOI: 10.3389/fonc.2024.1349536</identifier><identifier>PMID: 38764583</identifier><language>eng</language><publisher>Switzerland: Frontiers Media S.A</publisher><subject>histopathological examination ; lymphovascular invasion ; oncologic staging ; Oncology ; prognostic factors ; prostate cancer ; radical prostatectomy</subject><ispartof>Frontiers in oncology, 2024-05, Vol.14, p.1349536-1349536</ispartof><rights>Copyright © 2024 Karwacki, Łątkowska, Jarocki, Jaworski, Szuba, Poterek, Lemiński, Kaczmarek, Hałoń, Szydełko and Małkiewicz.</rights><rights>Copyright © 2024 Karwacki, Łątkowska, Jarocki, Jaworski, Szuba, Poterek, Lemiński, Kaczmarek, Hałoń, Szydełko and Małkiewicz 2024 Karwacki, Łątkowska, Jarocki, Jaworski, Szuba, Poterek, Lemiński, Kaczmarek, Hałoń, Szydełko and Małkiewicz</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c418t-e44df86fa6e5abddcfc34e17ec49891e826c7fce26a37379f319aa086b2ae93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11099271/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11099271/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38764583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karwacki, Jakub</creatorcontrib><creatorcontrib>Łątkowska, Małgorzata</creatorcontrib><creatorcontrib>Jarocki, Michał</creatorcontrib><creatorcontrib>Jaworski, Arkadiusz</creatorcontrib><creatorcontrib>Szuba, Przemysław</creatorcontrib><creatorcontrib>Poterek, Adrian</creatorcontrib><creatorcontrib>Lemiński, Artur</creatorcontrib><creatorcontrib>Kaczmarek, Krystian</creatorcontrib><creatorcontrib>Hałoń, Agnieszka</creatorcontrib><creatorcontrib>Szydełko, Tomasz</creatorcontrib><creatorcontrib>Małkiewicz, Bartosz</creatorcontrib><title>The clinical meaning of lymphovascular invasion: preoperative predictors and postoperative implications in prostate cancer - a retrospective study</title><title>Frontiers in oncology</title><addtitle>Front Oncol</addtitle><description><![CDATA[Lymphovascular invasion (LVI) is a pivotal histopathological parameter in prostate cancer (PCa), holding significant prognostic implications. Our study pursued a dual objective: firstly, to identify preoperative factors associated with LVI, aiming to unveil markers facilitating the recognition of patients prone to LVI during postoperative examination; and secondly, to assess postoperative outcomes correlated with LVI.
We retrospectively analyzed 861 nonmetastatic PCa patients who underwent radical prostatectomy (RP), investigating preoperative factors and postoperative outcomes. Surgical specimens were processed following established guidelines. Statistical analyses utilized non-parametric tests to assess the association between LVI and both pre- and postoperative factors. Furthermore, logistic regression analyses were utilized to develop models aimed at identifying the most significant predictors of LVI and pN1 status, respectively.
Numerous preoperative factors exhibited significant correlations with LVI, offering valuable clinical insights. Logistic regression identified magnetic resonance imaging (MRI)-based clinical tumor stage (cT) 3-4, biopsy Gleason Grading Group (GGG) 3-5, preoperative prostate specific antigen (PSA) ≥20 and percentage of positive biopsy cores (PPBC) ≥50% as the strongest preoperative predictors of LVI. Additionally, the study uncovered an association between LVI and postoperative outcomes, including postoperative PSA (
value <0.001), extracapsular extension (ECE) (<0.001), positive surgical margins (PSM) (<0.001), perineural invasion (PNI) (<0.001), pathological tumor stage (pT) (<0.001), pathological lymph node status (pN) (<0.001), postoperative GGG (<0.001), and operative time (0.023). Notably, the study revealed a novel and substantial association between LVI and an increased number of positive lymph nodes in pN+ patients in the univariate analysis (<0.001). Furthermore, we have found an association between LVI and pN1 status in the logistic regression analysis (odds ratio [OR] = 23.905;
0.001).
Our findings underscore the pivotal role of LVI in influencing the prognosis of prostate cancer (PCa). The study acknowledges the challenges associated with preoperative LVI assessment and emphasizes the need for future research to unravel the factors associated with this histopathological finding. Significantly, our research stands out as the first, to the best of our knowledge, to reveal the association between LVI and the number of positive lymph nodes in pN+ patients.]]></description><subject>histopathological examination</subject><subject>lymphovascular invasion</subject><subject>oncologic staging</subject><subject>Oncology</subject><subject>prognostic factors</subject><subject>prostate cancer</subject><subject>radical prostatectomy</subject><issn>2234-943X</issn><issn>2234-943X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkstuGyEUhkdVqyZK8wDdVCy7sTNchhm6qaqol0iRumgW3aFjONhEMzAFbMmv0Scujp00YcO5_d9B6G-a97Rdcj6oKxeDWbKWiSXlQnVcvmrOGeNioQT__fpZfNZc5nzf1iO7lrb8bXPGh16KbuDnzd-7DRIz-uANjGRCCD6sSXRk3E_zJu4gm-0IifhQQx_DJzInjDMmKH6Hh8R6U2LKBIIlc8zlf9NP81ixpcpyBdTh2oZS90EwmMiCAElYanVG86DIZWv375o3DsaMl6f7ovn17evd9Y_F7c_vN9dfbhdG0KEsUAjrBulAYgcra40zXCDt0Qg1KIoDk6Z3BpkE3vNeOU4VQDvIFQNU_KK5OVJthHs9Jz9B2usIXj8UYlprSMWbEXUHDBwYuxosExKZUm6wEmXnOksFYGV9PrLm7WpCazCUBOML6MtO8Bu9jjtNaasU62klfDwRUvyzxVz05LPBcYSAcZs1b7u-7bteiDpKj6OmflxO6J720FYfnKEPztAHZ-iTM6rmw_MHPikefcD_AfDFvBE</recordid><startdate>20240503</startdate><enddate>20240503</enddate><creator>Karwacki, Jakub</creator><creator>Łątkowska, Małgorzata</creator><creator>Jarocki, Michał</creator><creator>Jaworski, Arkadiusz</creator><creator>Szuba, Przemysław</creator><creator>Poterek, Adrian</creator><creator>Lemiński, Artur</creator><creator>Kaczmarek, Krystian</creator><creator>Hałoń, Agnieszka</creator><creator>Szydełko, Tomasz</creator><creator>Małkiewicz, Bartosz</creator><general>Frontiers Media S.A</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20240503</creationdate><title>The clinical meaning of lymphovascular invasion: preoperative predictors and postoperative implications in prostate cancer - a retrospective study</title><author>Karwacki, Jakub ; Łątkowska, Małgorzata ; Jarocki, Michał ; Jaworski, Arkadiusz ; Szuba, Przemysław ; Poterek, Adrian ; Lemiński, Artur ; Kaczmarek, Krystian ; Hałoń, Agnieszka ; Szydełko, Tomasz ; Małkiewicz, Bartosz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-e44df86fa6e5abddcfc34e17ec49891e826c7fce26a37379f319aa086b2ae93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>histopathological examination</topic><topic>lymphovascular invasion</topic><topic>oncologic staging</topic><topic>Oncology</topic><topic>prognostic factors</topic><topic>prostate cancer</topic><topic>radical prostatectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karwacki, Jakub</creatorcontrib><creatorcontrib>Łątkowska, Małgorzata</creatorcontrib><creatorcontrib>Jarocki, Michał</creatorcontrib><creatorcontrib>Jaworski, Arkadiusz</creatorcontrib><creatorcontrib>Szuba, Przemysław</creatorcontrib><creatorcontrib>Poterek, Adrian</creatorcontrib><creatorcontrib>Lemiński, Artur</creatorcontrib><creatorcontrib>Kaczmarek, Krystian</creatorcontrib><creatorcontrib>Hałoń, Agnieszka</creatorcontrib><creatorcontrib>Szydełko, Tomasz</creatorcontrib><creatorcontrib>Małkiewicz, Bartosz</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>Frontiers in oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karwacki, Jakub</au><au>Łątkowska, Małgorzata</au><au>Jarocki, Michał</au><au>Jaworski, Arkadiusz</au><au>Szuba, Przemysław</au><au>Poterek, Adrian</au><au>Lemiński, Artur</au><au>Kaczmarek, Krystian</au><au>Hałoń, Agnieszka</au><au>Szydełko, Tomasz</au><au>Małkiewicz, Bartosz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The clinical meaning of lymphovascular invasion: preoperative predictors and postoperative implications in prostate cancer - a retrospective study</atitle><jtitle>Frontiers in oncology</jtitle><addtitle>Front Oncol</addtitle><date>2024-05-03</date><risdate>2024</risdate><volume>14</volume><spage>1349536</spage><epage>1349536</epage><pages>1349536-1349536</pages><issn>2234-943X</issn><eissn>2234-943X</eissn><abstract><![CDATA[Lymphovascular invasion (LVI) is a pivotal histopathological parameter in prostate cancer (PCa), holding significant prognostic implications. Our study pursued a dual objective: firstly, to identify preoperative factors associated with LVI, aiming to unveil markers facilitating the recognition of patients prone to LVI during postoperative examination; and secondly, to assess postoperative outcomes correlated with LVI.
We retrospectively analyzed 861 nonmetastatic PCa patients who underwent radical prostatectomy (RP), investigating preoperative factors and postoperative outcomes. Surgical specimens were processed following established guidelines. Statistical analyses utilized non-parametric tests to assess the association between LVI and both pre- and postoperative factors. Furthermore, logistic regression analyses were utilized to develop models aimed at identifying the most significant predictors of LVI and pN1 status, respectively.
Numerous preoperative factors exhibited significant correlations with LVI, offering valuable clinical insights. Logistic regression identified magnetic resonance imaging (MRI)-based clinical tumor stage (cT) 3-4, biopsy Gleason Grading Group (GGG) 3-5, preoperative prostate specific antigen (PSA) ≥20 and percentage of positive biopsy cores (PPBC) ≥50% as the strongest preoperative predictors of LVI. Additionally, the study uncovered an association between LVI and postoperative outcomes, including postoperative PSA (
value <0.001), extracapsular extension (ECE) (<0.001), positive surgical margins (PSM) (<0.001), perineural invasion (PNI) (<0.001), pathological tumor stage (pT) (<0.001), pathological lymph node status (pN) (<0.001), postoperative GGG (<0.001), and operative time (0.023). Notably, the study revealed a novel and substantial association between LVI and an increased number of positive lymph nodes in pN+ patients in the univariate analysis (<0.001). Furthermore, we have found an association between LVI and pN1 status in the logistic regression analysis (odds ratio [OR] = 23.905;
0.001).
Our findings underscore the pivotal role of LVI in influencing the prognosis of prostate cancer (PCa). The study acknowledges the challenges associated with preoperative LVI assessment and emphasizes the need for future research to unravel the factors associated with this histopathological finding. Significantly, our research stands out as the first, to the best of our knowledge, to reveal the association between LVI and the number of positive lymph nodes in pN+ patients.]]></abstract><cop>Switzerland</cop><pub>Frontiers Media S.A</pub><pmid>38764583</pmid><doi>10.3389/fonc.2024.1349536</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | histopathological examination lymphovascular invasion oncologic staging Oncology prognostic factors prostate cancer radical prostatectomy |
| title | The clinical meaning of lymphovascular invasion: preoperative predictors and postoperative implications in prostate cancer - a retrospective study |
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