Contribution of genetic factors to high rates of neonatal hyperbilirubinaemia on the Thailand-Myanmar border

Very high unconjugated bilirubin plasma concentrations in neonates (neonatal hyperbilirubinaemia; NH) may cause neurologic damage (kernicterus). Both increased red blood cell turn-over and immaturity of hepatic glucuronidation contribute to neonatal hyperbilirubinaemia. The incidence of NH requiring...

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Published in:PLOS global public health 2022, Vol.2 (6), p.e0000475-e0000475
Main Authors: Bancone, Germana, Gornsawun, Gornpan, Peerawaranun, Pimnara, Penpitchaporn, Penporn, Paw, Moo Kho, Poe, Day Day, Win, December, Cicelia, Naw, Mukaka, Mavuto, Archasuksan, Laypaw, Thielemans, Laurence, Nosten, Francois, White, Nicholas J, McGready, Rose, Carrara, Verena I
Format: Article
Language:English
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Summary:Very high unconjugated bilirubin plasma concentrations in neonates (neonatal hyperbilirubinaemia; NH) may cause neurologic damage (kernicterus). Both increased red blood cell turn-over and immaturity of hepatic glucuronidation contribute to neonatal hyperbilirubinaemia. The incidence of NH requiring phototherapy during the first week of life on the Thailand-Myanmar border is high (approximately 25%). On the Thailand-Myanmar border we investigated the contribution of genetic risk factors to high bilirubin levels in the first month of life in 1596 neonates enrolled in a prospective observational birth cohort study. Lower gestational age (
ISSN:2767-3375
2767-3375
DOI:10.1371/journal.pgph.0000475