Management of Allogeneic Stem Cell Transplantation for High-Risk AML following SARS-CoV-2 Associated Pancytopenia with Marked Bone Marrow Biopsy Alterations

The present study describes a patient aged 70 with very high-risk AML who successfully received a nonmyeloablative matched unrelated donor allograft shortly following SARS-CoV-2 infection, which manifested with mild cough, interstitial abnormalities on chest CT, and pancytopenia with profound bone m...

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Bibliographic Details
Published in:Case reports in hematology 2021-01, Vol.2021, p.8843063-7
Main Authors: Kaparou, Maria, Rudzki, Zbigniew, Giles, Hannah, Murthy, Vidhya, Srinath, Swathy, Lloyd, Rebecca, Ahmed, Maria Zahid, Salhan, Beena, Chauhan, Saleena, Kishore, Bhuvan, Lovell, Richard, Horgan, Claire, Paneesha, Shankara, Xenou, Evgenia, Lokare, Anand, Ewing, Joanne, Dassanayake, Hansini, Nikolousis, Emmanouil, Kanellopoulos, Alexandros
Format: Article
Language:English
Subjects:
Biopsy
Blood platelets
Blood tests
Bone marrow
Bone marrow examination
Case Report
Case reports
Chemotherapy
Coronaviruses
COVID-19
Health aspects
Hematology
Hematopoietic stem cells
Infections
Lymphocytes
Medical imaging
Medical research
Medicine, Experimental
Morphology
Multiple myeloma
Neutrophils
Patients
Severe acute respiratory syndrome coronavirus 2
Stem cell transplantation
Stem cells
Thrombocytopenia
Transplantation
Transplantation of organs, tissues, etc
Transplants & implants
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Summary:The present study describes a patient aged 70 with very high-risk AML who successfully received a nonmyeloablative matched unrelated donor allograft shortly following SARS-CoV-2 infection, which manifested with mild cough, interstitial abnormalities on chest CT, and pancytopenia with profound bone marrow biopsy histological alterations. In parallel, our study provides bone marrow biopsy data in a series of contemporary patients with serious haematological diseases who had a bone marrow biopsy performed within two weeks of PCR confirmation of SARS-CoV-2 infection. This study is notable because there are no published data describing the bone marrow biopsy changes observed in patients with haematological malignancies and SARS-CoV-2 infection. Finally, it is suggested that nonmyeloablative hematopoietic stem cell transplantation for very high-risk haematological malignancies can be successfully performed following recovery from SARS-CoV-2 infection.
ISSN:2090-6560
2090-6579
DOI:10.1155/2021/8843063