Antimicrobial Stewardship Techniques for Critically Ill Patients with Pneumonia

Pneumonia is common in the intensive care unit (ICU), infecting 27% of all critically ill patients. Given the high prevalence of this disease state in the ICU, optimizing antimicrobial therapy while minimizing toxicities is of utmost importance. Inappropriate antimicrobial use can increase the risk...

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Bibliographic Details
Published in:Antibiotics (Basel) 2023-02, Vol.12 (2), p.295
Main Authors: Adams, Jenna, Ferguson, Kaitlin, Hirschy, RaeAnn, Konopka, Erica, Meckel, Jordan, Benanti, Grace, Kuhrau, Shannon, Albarillo, Fritzie, Chang, Kevin, Santarossa, Maressa, Sapozhnikov, Julia, Hoff, Brian, Rech, Megan A
Format: Article
Language:English
Subjects:
Allergic reactions
Antibiotics
Antimicrobial agents
Antimicrobial resistance
antimicrobial stewardship
Bacterial infections
Bacterial pneumonia
Cohort analysis
Complications
critically ill
Development and progression
Drug resistance
Health care
Hospital patients
Hospitals
Hypersensitivity
Methicillin
methicillin-resistant Staphylococcus aureus
Methods
Microbiology
Optimization
Organisms
Patients
Pneumonia
Polymerase chain reaction
Procalcitonin
Prolongation
Pseudomonas aeruginosa
Review
Staphylococcus infections
Streptococcus infections
Tazobactam
Thrombocytopenia
Thyroid gland
Toxicity
Tumor necrosis factor-TNF
Vancomycin
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Summary:Pneumonia is common in the intensive care unit (ICU), infecting 27% of all critically ill patients. Given the high prevalence of this disease state in the ICU, optimizing antimicrobial therapy while minimizing toxicities is of utmost importance. Inappropriate antimicrobial use can increase the risk of antimicrobial resistance, infection, allergic reaction, and other complications from antimicrobial use (e.g., QTc prolongation, thrombocytopenia). This review article aims to discuss methods to optimize antimicrobial treatment in patients with pneumonia, including the following: procalcitonin use, utilization of methicillin-resistant nares testing to determine need for vancomycin therapy, utilization of the Biofire FilmArray pneumonia polymerase chain reaction (PCR), and microbiology reporting techniques.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics12020295