Long-term cognitive training enhances fluid cognition and brain connectivity in individuals with MCI

Amnestic mild cognitive impairment (aMCI) is a risk factor for Alzheimer’s disease (AD). Multi-domain cognitive training (CT) may slow cognitive decline and delay AD onset. However, most work involves short interventions, targeting single cognitive domains or lacking active controls. We conducted a...

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Bibliographic Details
Published in:Translational psychiatry 2024-10, Vol.14 (1), p.447-9, Article 447
Main Authors: Gozdas, Elveda, Avelar-Pereira, Bárbara, Fingerhut, Hannah, Dacorro, Lauren, Jo, Booil, Williams, Leanne, O’Hara, Ruth, Hosseini, S. M. Hadi
Format: Article
Language:English
Subjects:
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Aged
Behavioral Sciences
Biological Psychology
Brain - diagnostic imaging
Brain - physiopathology
Cognition & reasoning
Cognition - physiology
Cognitive Behavioral Therapy - methods
Cognitive Dysfunction - diagnostic imaging
Cognitive Dysfunction - physiopathology
Cognitive Dysfunction - rehabilitation
Cognitive Training
Executive Function - physiology
Female
Humans
Intervention
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Memory
Middle Aged
Neurosciences
Pharmacotherapy
Psychiatry
Single-Blind Method
White Matter - diagnostic imaging
White Matter - physiopathology
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Summary:Amnestic mild cognitive impairment (aMCI) is a risk factor for Alzheimer’s disease (AD). Multi-domain cognitive training (CT) may slow cognitive decline and delay AD onset. However, most work involves short interventions, targeting single cognitive domains or lacking active controls. We conducted a single-blind randomized controlled trial to investigate the effect of a 6-month, multi-domain CT on Fluid Cognition, functional connectivity in memory and executive functioning networks (primary outcomes), and white matter microstructural properties (secondary outcome) in aMCI. Sixty participants were randomly assigned to either a multi-domain CT or crossword training (CW) group, and thirty-four participants completed the intervention. We found a significant group-by-time interaction in Fluid Cognition ( p  = 0.007, F (1,28) = 8.26, Cohen’s d  = 0.38, 95% confidence interval [CI]: 2.45–14.4), with 90% of CT patients showing post-intervention improvements ( p  
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-024-03153-x