Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents

• Published in: Heliyon 2020-09, Vol.6 (9), p.e04956-e04956, Article e04956
• Main Authors: Abdelhameed, Reda M., Darwesh, Osama M., El-Shahat, Mahmoud
• Format: Article
• Language: English
• Subjects: Anti-bacterial activity; Anti-fungal activity; antimicrobial properties; Bacillus cereus; Candida albicans; drugs; Escherichia coli; fungi; Gram-negative bacteria; Gram-positive bacteria; Hydrazinylpyrido[2,3-d]pyrimidin-4-one; moieties; Organic chemistry; Pharmaceutical chemistry; Pyrido[2,3-d]pyrimidin-4-one; Salmonella Typhi; Staphylococcus
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2020.e04956

Combination of arylidene hydrazinyl moiety with pyrido[2,3-d]pyrimidin-4-one skeleton in compounds 7‒26 results in the output of unprecedented anti-microbial agents. Arylidene hydrazinyl based on Pyrido[2,3-d]pyrimidin-4-one analoges 7‒26 prepared by the treatment of [2,3-d]pyrimidin-4-ones 6a,b with various aromatic aldehydes. The antimicrobial action for recently synthesized compounds was considered towards gram positive bacterial species (Staphylococcus aurous ATCC- 47077; Bacillus cereus ATCC-12228), gram negative bacterial species (Escherichia coli ATCC-25922; Salmonella typhi ATCC-15566) and Candida albicans ATCC-10231 as fungal strains. The antimicrobial action expanded by expanding the electron donating group in position 2 and 5 for Pyrido[2,3-d]pyrimidin-4-one core. Derivatives 13, 14, 15, 16 and 12; individually appeared hopeful anti-microbial action towards all strains utilized with inhibition zone higher than that of standard reference drug with lowest MIC. Organic chemistry, Pharmaceutical chemistry, Pyrido[2,3-d]pyrimidin-4-one; Hydrazinylpyrido[2,3-d]pyrimidin-4-one; Anti-bacterial activity; Anti-fungal activity.