Exploring Multi-Parameter Effects on Iron Oxide Nanoparticle Synthesis by SAXS Analysis

Iron oxide nanoparticles (IONs) are extensively used in biomedical applications due to their unique magnetic properties. This study optimized ION synthesis via the co-precipitation method, exploring the impact of the reactant concentrations (Fe(II) and Fe(III)), NaOH concentration, temperature (30 °...

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Bibliographic Details
Published in:Crystals (Basel) 2024-11, Vol.14 (11), p.961
Main Authors: Eigenfeld, Marco, Reindl, Marco, Sun, Xiao, Schwaminger, Sebastian P
Format: Article
Language:English
Subjects:
biomedical applications
Biomedical engineering
Biomedical materials
Caustic soda
Chemical synthesis
Comparative analysis
Cost analysis
Drug delivery systems
Drugs
Experiments
Ferric oxide
Hyperthermia
Iron compounds
iron oxide nanoparticles
Iron oxides
Magnetic fields
Magnetic properties
Magnetic resonance imaging
Medical research
nanoparticle size
nanoparticle synthesis
Nanoparticles
Nucleation
nucleation and growth dynamics
Particle size
Small angle X ray scattering
Stirring
Vehicles
X-rays
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Summary:Iron oxide nanoparticles (IONs) are extensively used in biomedical applications due to their unique magnetic properties. This study optimized ION synthesis via the co-precipitation method, exploring the impact of the reactant concentrations (Fe(II) and Fe(III)), NaOH concentration, temperature (30 °C–80 °C), stirring speed (0–1000 rpm), and dosing rate (10–600 s) on particle size and growth. Using small-angle X-ray scattering (SAXS), we observed, for example, that higher temperatures (e.g., 67 °C compared with 53 °C) led to a 50% increase in particle size, while the stirring speed and NaOH concentration also influenced nucleation and aggregation. These results provide comprehensive insights into optimizing synthetic conditions for targeted applications in biomedical fields, such as drug delivery and magnetic resonance imaging (MRI), where precise control over nanoparticle size and properties is crucial.
ISSN:2073-4352
2073-4352
DOI:10.3390/cryst14110961