Antimicrobial Resistance in Sepsis Cases Due to Escherichia coli and Klebsiella pneumoniae : Pre-Pandemic Insights from a Single Center in Southwestern Romania

Sepsis is an uncontrolled reaction of the body to an infection, and if not effectively treated, it can progress to septic shock, multiple organ failure, and ultimately, death. To determine the resistance profile of ( ) and ( ) strains isolated in sepsis cases diagnosed at the Infectious Diseases Cli...

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Bibliographic Details
Published in:Healthcare (Basel) 2024-08, Vol.12 (17), p.1713
Main Authors: Giubelan, Lucian-Ion, Neacșu, Alexandru Ionuț, Rotaru-Zavaleanu, Alexandra Daniela, Osiac, Eugen
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
Bacteria
Bacterial infections
Coronaviruses
Drug resistance
E coli
Escherichia coli
Hospitals
Infections
Klebsiella pneumoniae
Mortality
Pandemics
Pathogens
Public health
Sepsis
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Summary:Sepsis is an uncontrolled reaction of the body to an infection, and if not effectively treated, it can progress to septic shock, multiple organ failure, and ultimately, death. To determine the resistance profile of ( ) and ( ) strains isolated in sepsis cases diagnosed at the Infectious Diseases Clinic in Craiova, Romania. The bacteria responsible for sepsis cases were identified using the Vitek 2 Systems version 06.01, which was then employed to assess their antimicrobial susceptibility (Global CLSI and Phenotypic 2017). We have identified 989 patients diagnosed with bacterial sepsis. Among these, 953 cases were caused by Gram-negative rods, with 415 attributed to and 278 to High levels of resistance to ampicillin were recorded for strains isolated in sepsis cases (64.6%); adding sulbactam lowers the level of resistance to 41.8%. Resistance to 3rd generation cephalosporins varied between 7.47 and 14.6% and another 3.41 to 11.1% are dose-dependent susceptibility strains. Resistance to carbapenems (i.e., ertapenem, meropenem) is low-2.18-2.42%. More than 95% of the tested strains were resistant to ampicillin and adding sulbactam as a β-lactamase inhibitor only halves that level. Resistance to 3rd generation cephalosporins varied between 20.7% and 22.5%; resistance levels for were notably higher than those for . Over 95% of strains showed resistance to ampicillin, and resistance to 3rd generation cephalosporins varied between 20.7% and 22.5%. Additionally, exhibited higher resistance to carbapenems (13.7-19.5%) compared to (2.18-2.42%). Antimicrobial resistance levels are generally lower than continental and national data, except for ampicillin and carbapenems (meropenem and ertapenem). strains are significantly more resistant than strains.
ISSN:2227-9032
2227-9032
DOI:10.3390/healthcare12171713