Early detection of Australian Aboriginal and Torres Strait Islander infants at high risk of adverse neurodevelopmental outcomes at 12 months corrected age: LEAP-CP prospective cohort study protocol

IntroductionNeurodevelopmental disorders (NDD), including cerebral palsy (CP), autism spectrum disorder (ASD) and foetal alcohol spectrum disorder (FASD), are characterised by impaired development of the early central nervous system, impacting cognitive and/or physical function. Early detection of N...

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Bibliographic Details
Published in:BMJ open 2022-01, Vol.12 (1), p.e053646
Main Authors: Luke, Carly R, Benfer, Katherine, Mick-Ramsamy, Leeann, Ware, Robert S, Reid, Natasha, Bos, Arend F, Bosanquet, Margot, Boyd, Roslyn N
Format: Article
Language:English
Subjects:
Australia - epidemiology
Australian Aboriginal and Torres Strait Islander Peoples
Autism
Autism Spectrum Disorder
Cerebral palsy
Cerebral Palsy - diagnosis
Cerebral Palsy - epidemiology
Child
Cohort analysis
developmental neurology & neurodisability
Early intervention
Female
Humans
Indigenous Peoples
Infant
Native peoples
Neurodevelopmental disorders
paediatric neurology
Paediatrics
Pediatrics
Pregnancy
Prospective Studies
rehabilitation medicine
Socioeconomic factors
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Summary:IntroductionNeurodevelopmental disorders (NDD), including cerebral palsy (CP), autism spectrum disorder (ASD) and foetal alcohol spectrum disorder (FASD), are characterised by impaired development of the early central nervous system, impacting cognitive and/or physical function. Early detection of NDD enables infants to be fast-tracked to early intervention services, optimising outcomes. Aboriginal and Torres Strait Islander infants may experience early life factors increasing their risk of neurodevelopmental vulnerability, which persist into later childhood, further compounding the health inequities experienced by First Nations peoples in Australia. The LEAP-CP prospective cohort study will investigate the efficacy of early screening programmes, implemented in Queensland, Australia to earlier identify Aboriginal and Torres Strait Islander infants who are ‘at risk’ of adverse neurodevelopmental outcomes (NDO) or NDD. Diagnostic accuracy and feasibility of early detection tools for identifying infants ‘at risk’ of a later diagnosis of adverse NDO or NDD will be determined.Methods and analysisAboriginal and/or Torres Strait Islander infants born in Queensland, Australia (birth years 2020–2022) will be invited to participate. Infants aged
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2021-053646