Novel Glycemic Index Based on Continuous Glucose Monitoring to Predict Poor Clinical Outcomes in Critically Ill Patients: A Pilot Study

• Published in: Frontiers in endocrinology (Lausanne) 2022-05, Vol.13, p.869451-869451
• Main Authors: Ha, Eun Yeong, Chung, Seung Min, Park, Il Rae, Lee, Yin Young, Choi, Eun Young, Moon, Jun Sung
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Blood Glucose; Blood Glucose Self-Monitoring; Critical Illness - therapy; Diabetes Mellitus; Endocrinology; Female; Glucose; Glycated Hemoglobin A - analysis; Glycemic Index; hospitals; Humans; intensive care units; Male; Middle Aged; Pilot Projects; Prospective Studies; technology
• ISSN: 1664-2392; 1664-2392
• DOI: 10.3389/fendo.2022.869451

We explored the prospective relationship between continuous glucose monitoring (CGM) metrics and clinical outcomes in patients admitted to the intensive care unit (ICU). We enrolled critically ill patients admitted to the medical ICU. Patients with an Acute Physiology and Chronic Health Evaluation (APACHE) score ≤9 or ICU stay ≤48 h were excluded. CGM was performed for five days, and standardized CGM metrics were analyzed. The duration of ICU stay and 28-day mortality rate were evaluated as outcomes. A total of 36 patients were included in this study (age [range], 49-88 years; men, 55.6%). The average APACHE score was 25.4 ± 8.3; 33 (91.7%) patients required ventilator support, and 16 (44.4%) patients had diabetes. The duration of ICU stay showed a positive correlation with the average blood glucose level, glucose management indicator (GMI), time above range, and GMI minus (-) glycated hemoglobin (HbA1c). Eight (22.2%) patients died within 28 days, and their average blood glucose levels, GMI, and GMI-HbA1c were significantly higher than those of survivors (p