Clinical Antibiotic-resistant Acinetobacter baumannii Strains with Higher Susceptibility to Environmental Phages than Antibiotic-sensitive Strains

Antibiotic-resistant Acinetobacter baumannii is associated with nosocomial infections worldwide. Here, we used clinically isolated A. baumannii strains as models to demonstrate whether antibiotic resistance is correlated with an increased susceptibility to bacteriophages. In this study, 24 active ph...

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Bibliographic Details
Published in:Scientific reports 2017-07, Vol.7 (1), p.6319-10, Article 6319
Main Authors: Chen, Li-Kuang, Kuo, Shu-Chen, Chang, Kai-Chih, Cheng, Chieh-Chen, Yu, Pei-Ying, Chang, Chih-Hui, Chen, Tren-Yi, Tseng, Chun-Chieh
Format: Article
Language:English
Subjects:
38/77
631/326/1321
631/326/41/2529
Acinetobacter baumannii
Acinetobacter baumannii - drug effects
Acinetobacter baumannii - growth & development
Acinetobacter baumannii - virology
Adaptation
Anti-Bacterial Agents - pharmacology
Antibiotic resistance
Antibiotics
Bacteriophage Typing - methods
Bacteriophages - physiology
Drug resistance
Drug Resistance, Multiple, Bacterial
Humanities and Social Sciences
Microbial Sensitivity Tests
multidisciplinary
Nosocomial infection
Nosocomial infections
Phage typing
Phages
Science
Science (multidisciplinary)
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Summary:Antibiotic-resistant Acinetobacter baumannii is associated with nosocomial infections worldwide. Here, we used clinically isolated A. baumannii strains as models to demonstrate whether antibiotic resistance is correlated with an increased susceptibility to bacteriophages. In this study, 24 active phages capable of infecting A. baumannii were isolated from various environments, and the susceptibilities of both antibiotic-sensitive and antibiotic-resistant strains of A. baumannii to different phages were compared. In our study, a total of 403 clinically isolated A. baumannii strains were identified. On average, the phage infection percentage of the antibiotic-resistant A. baumannii strains was 84% (from 81–86%), whereas the infection percentage in the antibiotic-sensitive A. baumannii strains was only 56.5% (from 49–64%). In addition, the risk of phage infection for A. baumannii was significantly increased in the strains that were resistant to at least four antibiotics and exhibited a dose-dependent response ( p -trend 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-06688-w