The effects of gut microbiome manipulation on glycemic indices in patients with non-alcoholic fatty liver disease: a comprehensive umbrella review

Background Type 2 diabetes mellitus (T2DM) is a significant risk factor for non-alcoholic fatty liver disease (NAFLD). Increased fasting blood sugar (FBS), fasting insulin (FI), and insulin resistance (HOMA-IR) are observed in patients with NAFLD. Gut microbial modulation using prebiotics, probiotic...

Full description

Saved in:
Bibliographic Details
Published in:Nutrition & diabetes 2024-05, Vol.14 (1), p.25-14, Article 25
Main Authors: Vakilpour, Azin, Amini-Salehi, Ehsan, Soltani Moghadam, Arman, Keivanlou, Mohammad-Hossein, Letafatkar, Negin, Habibi, Arman, Hashemi, Mohammad, Eslami, Negar, Zare, Reza, Norouzi, Naeim, Delam, Hamed, Joukar, Farahnaz, Mansour-Ghanaei, Fariborz, Hassanipour, Soheil, Samethadka Nayak, Sandeep
Format: Article
Language:English
Subjects:
13
64
692/699/1503
692/699/2743
82
Blood Glucose - metabolism
Clinical Nutrition
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - microbiology
Diabetes Mellitus, Type 2 - therapy
Epidemiology
Gastrointestinal Microbiome
Glycemic Index
Humans
Insulin - blood
Insulin Resistance
Internal Medicine
Liver diseases
Medicine
Medicine & Public Health
Metabolic Diseases
Non-alcoholic Fatty Liver Disease - blood
Non-alcoholic Fatty Liver Disease - diet therapy
Non-alcoholic Fatty Liver Disease - microbiology
Non-alcoholic Fatty Liver Disease - therapy
Prebiotics
Prebiotics - administration & dosage
Probiotics
Probiotics - administration & dosage
Probiotics - therapeutic use
Review Article
Synbiotics - administration & dosage
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Type 2 diabetes mellitus (T2DM) is a significant risk factor for non-alcoholic fatty liver disease (NAFLD). Increased fasting blood sugar (FBS), fasting insulin (FI), and insulin resistance (HOMA-IR) are observed in patients with NAFLD. Gut microbial modulation using prebiotics, probiotics, and synbiotics has shown promise in NAFLD treatment. This meta-umbrella study aimed to investigate the effects of gut microbial modulation on glycemic indices in patients with NAFLD and discuss potential mechanisms of action. Methods A systematic search was conducted in PubMed, Web of Science, Scopus, and Cochrane Library until March 2023 for meta-analyses evaluating the effects of probiotics, prebiotics, and synbiotics on patients with NAFLD. Random-effect models, sensitivity analysis, and subgroup analysis were employed. Results Gut microbial therapy significantly decreased HOMA-IR (ES: −0.41; 95%CI: −0.52, −0.31; P  
ISSN:2044-4052
2044-4052
DOI:10.1038/s41387-024-00281-7