Dorsolateral prefrontal cortex to ipsilateral primary motor cortex intercortical interactions during inhibitory control enhance response inhibition in open-skill athletes

• Published in: Scientific reports 2024-10, Vol.14 (1), p.24345-15, Article 24345
• Main Authors: Wang, Yanqiu, Lin, Yitong, Ran, Qiuyan, Cao, Na, Xia, Xue, Tan, Xiaoying, Wu, Yin, Zhang, Jian, Liu, Ke, Liu, Hui
• Format: Article
• Language: English
• Subjects: 631/477; 631/477/2811; Adult; Athletes; Cortex (motor); Dorsolateral Prefrontal Cortex - physiology; Evoked Potentials, Motor - physiology; Female; Humanities and Social Sciences; Humans; Inhibition, Psychological; Magnetic fields; Male; Motor Cortex - physiology; Motor evoked potentials; Motor skill; Motor task performance; multidisciplinary; Neural networks; Physical fitness; Prefrontal cortex; Prefrontal Cortex - physiology; Reaction Time - physiology; Reaction time task; Science; Science (multidisciplinary); Skills; Sports training; Training; Transcranial Magnetic Stimulation; Young Adult
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-75151-4

Numerous studies have reported that long-term sports training can affect inhibitory control and induce brain functional alterations. However, the influence of environmental dynamics in sports training on inter-cortical connectivity has not been well studied. In the current study, we used twin-coil transcranial magnetic stimulation to investigate the functional connectivity between dorsolateral prefrontal cortex (DLPFC) and ipsilateral primary motor cortex (M1) during proactive and reactive inhibition in participants with sports skills in dynamic environment (open-skill experts), stable environment (closed-skill experts), and no sports skills (controls). Using a modified stop signal task, proactive inhibition was measured by the response delay effect (RDE), and reactive inhibition was measured by the stop-signal reaction time (SSRT). Intra-hemispheric DLPFC-M1 interactions and single pulse motor-evoked potentials (MEPs) were measured during the task. A stronger inhibitory effect of the DLPFC over M1 was observed during early reactive control stages compared to baseline levels. In addition, this inhibitory effect was pronounced when comparing open-skill experts to non-athlete controls, a relationship that was significantly correlated with superior reactive control performance. Furthermore, DLPFC to M1 influencing direction shifted from late proactive control to reactive control. Behavioral results also demonstrated enhanced proactive control abilities in open-skill experts relative to controls. Such enhancement may be due to the combination of environmental complexity and physical fitness in long-term skill training.