Akkermansia muciniphila Associated with Improved Linear Growth among Young Children, Democratic Republic of the Congo

To investigate the association between enteric pathogens, fecal microbes, and child growth, we conducted a prospective cohort study of 236 children 3 pathogens in their feces. We observed larger increases in height-for-age-z-scores from baseline to the 6-month follow-up among children with Akkermans...

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Bibliographic Details
Published in:Emerging infectious diseases 2023-01, Vol.29 (1), p.81-88
Main Authors: George, Christine Marie, Birindwa, Alves, Li, Shan, Williams, Camille, Kuhl, Jennifer, Thomas, Elizabeth, François, Ruthly, Presence, Amani Sanvura, Claude, Bisimwa Rusanga Jean, Mirindi, Patrick, Bisimwa, Lucien, Perin, Jamie, Stine, O Colin
Format: Article
Language:English
Subjects:
Age
Akkermansia muciniphila
anthropometrics
Associated with Improved Linear Growth among Young Children, Democratic Republic of the Congo
bacteria
Bacterial infections
Body height
Body measurements
Breastfeeding & lactation
Campylobacter
Caregivers
Child
child growth
Child, Preschool
Children & youth
Cohort analysis
Complications and side effects
Cryptosporidiosis
Cryptosporidium
Democratic Republic of the Congo - epidemiology
Diarrhea
Education
Feces
Food
Gram-negative bacteria
Growth
Growth disorders
Health aspects
Households
Humans
Infections
Laboratories
Microorganisms
Pathogens
Pediatric research
Pediatrics
Physiological aspects
prospective cohort studies
Prospective Studies
Questionnaires
Regression analysis
Risk factors
Rural children
Statistics
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Description
Summary:To investigate the association between enteric pathogens, fecal microbes, and child growth, we conducted a prospective cohort study of 236 children 3 pathogens in their feces. We observed larger increases in height-for-age-z-scores from baseline to the 6-month follow-up among children with Akkermansia muciniphila in their feces (coefficient 0.02 [95% CI 0.0001-0.04]; p = 0.04). Children with Cryptosporidium in their feces had larger declines in weight-for-height/length z-scores from baseline to the 6-month follow-up (coefficient -0.03 [95% CI -0.05 to -0.005]; p = 0.02). Our study showed high prevalence of enteric pathogens among this pediatric cohort and suggests A. muciniphila can potentially serve as a probiotic to improve child growth.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2901.212118