Effect of lipid accumulation product on the development of hypertension among nondiabetic individuals in eastern China: A cross‐sectional study

This study was aimed at assessing the risk factors for hypertension (HTN) and prehypertension (PHT) in order to clarify the role of lipid accumulation product (LAP) in the development of HTN among nondiabetic individuals. A large cross‐sectional study was conducted in community health service center...

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Bibliographic Details
Published in:The journal of clinical hypertension (Greenwich, Conn.) Conn.), 2023-08, Vol.25 (8), p.784-793
Main Authors: Shu, Li, Zhang, Jiaye, Jia, Linlin, Wang, Jinchen, Han, Ziyan
Format: Article
Language:English
Subjects:
Abdomen
Adults
Blood pressure
Body Mass Index
China - epidemiology
Cross-Sectional Studies
Developing countries
Diabetes
Family medical history
Fasting
Female
Humans
Hypertension
Hypertension - epidemiology
interaction
LAP
LDCs
Lipid Accumulation Product
Lipids
Male
Marital status
nondiabetic
Obesity
Obesity - epidemiology
Original
Prehypertension
Public health
Risk Factors
Smoking
Software
Statistical analysis
Womens health
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Summary:This study was aimed at assessing the risk factors for hypertension (HTN) and prehypertension (PHT) in order to clarify the role of lipid accumulation product (LAP) in the development of HTN among nondiabetic individuals. A large cross‐sectional study was conducted in community health service centers in urban Bengbu, Anhui Province, China. All participants completed an interview questionnaire and procedures to obtain physical measurements and biochemical indicators. Multivariate logistic regression was used to test for the prevalence of HTN and PHT in relation to each quartile increase in LAP level and family history of HTN. The resulting interaction effects were evaluated by relative excess risk of interaction (RERI), attributable proportion due to interaction (AP), and synergy index (SI). A total of 7733 subjects were enrolled in the study. The overall prevalence rates of PHT and HTN were 37.1% and 24.8%, respectively. After adjusting for confounding factors, multinomial logistic regression analysis showed that compared with subjects in LAP quartile 1, those in quartile 3 (OR, 1.257; 95% CI, 1.062–1.494) and quartile 4 (OR, 1.323; 95% CI, 1.101–1.592) had a significantly higher risk for HTN (p for trend 
ISSN:1524-6175
1751-7176
DOI:10.1111/jch.14696