A rare case of naturally occurring allo anti-Jk(a) missed in manual screening test on tube method

Background: Antibodies to the Kidd blood group are mainly red blood cell (RBC) immune, but a few reports on naturally occurring antibodies have been documented. Aim: The aim of this study is to study the anti-Jk(a) for its unusual reactivity with different serological methods. Materials and Methods:...

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Bibliographic Details
Published in:Asian journal of transfusion science 2020-01, Vol.14 (1), p.60-62
Main Authors: Kanani, Ashish, Senjaliya, Snehal, Rajapara, Manisha, Gupta, Anurag, Joshi, Sanmukh
Format: Article
Language:English
Subjects:
alloanti-jk(a)
Analysis
Antibodies
Blood & organ donations
Blood donation
Case Report
Case reports
Health screening
healthy blood donor
Medical screening
Methods
naturally occurring
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Summary:Background: Antibodies to the Kidd blood group are mainly red blood cell (RBC) immune, but a few reports on naturally occurring antibodies have been documented. Aim: The aim of this study is to study the anti-Jk(a) for its unusual reactivity with different serological methods. Materials and Methods: Donor's plasma was tested with RBCs from in house donors and commercial panels by manual and automated devices. Results: A 36-year-old male blood donor with naturally occurring anti-Jk(a) is detected by solid-phase assays and the gel card technique but not by the tube method. The IgG antibody with the titer of >32 was not a complement-fixing hemolysin, showed a reduced reactivity with enzyme-treated RBCs, and was detectable through 8 months' follow-up period. The donor was typed as (Jk(a−). Conclusion: An unusual naturally occurring anti-Jk(a) detected by solid-phase red-cell adherence but not reacting by tube technique reflected on the sensitivity of the methods used.
ISSN:0973-6247
1998-3565
DOI:10.4103/ajts.AJTS_104_19