GALNT14: An Emerging Marker Capable of Predicting Therapeutic Outcomes in Multiple Cancers

Members of the polypeptide -acetylgalactosaminyltransferase (GALNT) family function as the initiating enzymes that catalyze mucin-type O-glycosylation of proteins, and their dysregulated expression can alter cancer cell behaviors such as de novo occurrence, proliferation, migration, metastasis, and...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2020-02, Vol.21 (4), p.1491
Main Authors: Lin, Wey-Ran, Yeh, Chau-Ting
Format: Article
Language:English
Subjects:
biomarker
cancer
polypeptide n-acetylgalactosaminyltransferase
Review
single nucleotide polymorphism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Members of the polypeptide -acetylgalactosaminyltransferase (GALNT) family function as the initiating enzymes that catalyze mucin-type O-glycosylation of proteins, and their dysregulated expression can alter cancer cell behaviors such as de novo occurrence, proliferation, migration, metastasis, and drug resistance. Recent studies have demonstrated that one of the family's members, GALNT14, is aberrantly expressed in multiple cancers and involved in a variety of biological functions. Moreover, the single nucleotide polymorphisms (SNPs) of -rs9679162 have been shown to predict therapeutic outcomes in patients with hepatocellular carcinoma as well as several other different types of gastrointestinal cancer. This review summarizes the structural features of GANLT14, its functional roles, and the predictive values of genotypes and enzyme levels in multiple cancers receiving distinct anticancer therapies.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms21041491