Low maternal iodine intake and early pregnancy hypothyroxinemia: Possible repercussions for children

Recent studies have shown that early pregnancy hypothyroxinemia (lower free thyroxin [FT4] and normal thyroid stimulating hormone [TSH] concentration) has deleterious effects on neuro-intellectual development of children. This study was designed to know its incidence in local pregnant women. Urinary...

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Published in:Indian journal of endocrinology and metabolism 2014-07, Vol.18 (4), p.526-530
Main Authors: Elahi, Shan, Nagra, Saeed Ahmad
Format: Article
Language:English
Subjects:
Diagnosis
Fetuses
Hormones
Hospitals
Iodine
Laboratories
Maternal-fetal exchange
Medical research
Medicine, Experimental
Original
Pregnancy
Pregnancy, Complications of
Studies
Thyroid diseases
thyroid hormone
thyroid stimulating hormone
Urine
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Nagra, Saeed Ahmad
description Recent studies have shown that early pregnancy hypothyroxinemia (lower free thyroxin [FT4] and normal thyroid stimulating hormone [TSH] concentration) has deleterious effects on neuro-intellectual development of children. This study was designed to know its incidence in local pregnant women. Urinary iodine (UI) and serum thyroid related hormone (FT4, free triiodothyronine [FT3], and TSH) were determined in 254 pregnant women during the first trimester. UI and thyroid related hormones were determined by colorimetric (Sandell-Kolthoff) and radioimmunoassay method respectively. Most of the pregnant women (n = 202; 79.5%) were iodine deficient (ID; UI
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This study was designed to know its incidence in local pregnant women. Urinary iodine (UI) and serum thyroid related hormone (FT4, free triiodothyronine [FT3], and TSH) were determined in 254 pregnant women during the first trimester. UI and thyroid related hormones were determined by colorimetric (Sandell-Kolthoff) and radioimmunoassay method respectively. Most of the pregnant women (n = 202; 79.5%) were iodine deficient (ID; UI &lt;100 μg/L) and only 52 (20.5%) women were taking sufficient iodine (IS; UI ≥ 100 μg/L). Mean levels of FT4, FT3, and TSH were 13.0 ± 2.8 pmol/L, 3.8 ± 1.1 pmol/L and 1.2 ± 1.1 mIU/L, respectively. Maternal FT4 levels were significantly correlated with UI (r = 0.36; P &lt; 0.001). Mean FT4 level in IS women was significantly (P &lt; 0.05) higher than ID women. However, mean FT3 and TSH levels were not significantly different in both groups. FT4 reference range in IS pregnant women was 10.2-19.4 pmol/L. Hypothyroxinemia (FT4 &lt;10.2 pmol/L and TSH &lt;2.5 mIU/L) was diagnosed in 30 (11.8%) pregnant women. Its incidence was almost entirely confined to ID pregnant women with an odd ratio of 8.5 (95% confidence interval: 1.1-64.3). About 12% pregnant women residing in urban areas of Pakistan are hypothyroxinemic because of low iodine intake.</description><identifier>ISSN: 2230-8210</identifier><identifier>EISSN: 2230-9500</identifier><identifier>DOI: 10.4103/2230-8210.137513</identifier><identifier>PMID: 25143911</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. 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subjects Diagnosis
Fetuses
Hormones
Hospitals
Iodine
Laboratories
Maternal-fetal exchange
Medical research
Medicine, Experimental
Original
Pregnancy
Pregnancy, Complications of
Studies
Thyroid diseases
thyroid hormone
thyroid stimulating hormone
Urine
title Low maternal iodine intake and early pregnancy hypothyroxinemia: Possible repercussions for children
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