Accelerated Early Vascular Aging Among Adolescents With Obesity and/or Type 2 Diabetes Mellitus

Background The normal rate of subclinical vascular aging from adolescence to young adulthood has not been well-characterized. We conducted a 5-year longitudinal study among adolescents with normal-weight, obesity, and/or type 2 diabetes mellitus to examine trajectories of early vascular aging. Metho...

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Bibliographic Details
Published in:Journal of the American Heart Association 2020-05, Vol.9 (10), p.e014891
Main Authors: Ryder, Justin R, Northrop, Elise, Rudser, Kyle D, Kelly, Aaron S, Gao, Zhiqian, Khoury, Philip R, Kimball, Thomas R, Dolan, Lawrence M, Urbina, Elaine M
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Blood Pressure
cardiovascular
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - physiopathology
Carotid Intima-Media Thickness
Carotid-Femoral Pulse Wave Velocity
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - epidemiology
Disease Progression
Female
Heart Disease Risk Factors
Humans
longitudinal
Longitudinal Studies
Male
Original Research
Pediatric Obesity - diagnosis
Pediatric Obesity - epidemiology
Prognosis
Risk Assessment
subclinical
Time Factors
United States - epidemiology
Vascular Stiffness
Young Adult
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Summary:Background The normal rate of subclinical vascular aging from adolescence to young adulthood has not been well-characterized. We conducted a 5-year longitudinal study among adolescents with normal-weight, obesity, and/or type 2 diabetes mellitus to examine trajectories of early vascular aging. Methods and Results Adolescents (mean [SD] age 17.6 [3.5]; 35.3% male) had either normal weight (n=141), obesity (n=156), or type 2 diabetes mellitus (n=151) at baseline. Primary metrics used for early vascular aging included measures of vascular structure (carotid intima-media thickness [cIMT]; common, internal, and bulb) and arterial stiffness (carotid-femoral pulse wave velocity, and augmentation index). Longitudinal (5-year) outcomes were examined using generalized estimating equations adjusting for baseline value, sex, race, and age. Compared with participants with normal weight, those with obesity had greater positive change in common cIMT (0.05 mm [0.03, 0.06];
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.119.014891