Time-restricted feeding in rest phase alters IgE/mast cell–mediated allergic reaction in mice

• Published in: Allergology International 2020-04, Vol.69 (2), p.296-299
• Main Authors: Nakamura, Yuki, Ishimaru, Kayoko, Nakao, Atsuhito
• Format: Article
• Language: English
• ISSN: 1323-8930; 1440-1592
• DOI: 10.1016/j.alit.2019.09.004

Dear Editor, The circadian clock, which consists of a cell-autonomous transcription-translation feedback loop involving several "clock genes," regulates the timing of cellular activities by controlling a large proportion of genes in a cyclic manner. In mast cells, the clock gene Period2 (Per2), the expression of which exhibits a - 24-h oscillation, negatively regulates expression of the high-affinity IgE receptor (FcεRI), thereby contributing to the day-night variation in IgE-mediated mast cell activation in mice. Accordingly, the extent of passive cutaneous anaphylactic (PCA) reaction, a classical model of IgE/mast cell-mediated allergic reaction, in mice exhibits a peak during the "rest phase" (light period of the light/dark cycle in nocturnal mice) and a nadir during the "active phase" (dark period), when PER2 levels in mast cells decrease and increase, respectively. Circadian clock activity in peripheral cells is strongly influenced by the time of day at which feeding occurs.