A multidisciplinary approach for the treatment of GIST liver metastasis

Advanced gastrointestinal stromal tumors (GISTs) can metastasize and recur after a long remission period, resulting in serious morbidity, mortality, and complex management issues. A 67-year-old woman presented with epigastric fullness, mild jaundice and weight loss with a history of a bowel resectio...

Full description

Saved in:
Bibliographic Details
Published in:World journal of surgical oncology 2008-05, Vol.6 (1), p.46-46, Article 46
Main Authors: Radkani, Pejman, Ghersi, Marcelo M, Paramo, Juan C, Mesko, Thomas W
Format: Article
Language:English
Subjects:
Aged
Benzamides
Care and treatment
Case Report
Case studies
Combined Modality Therapy
Diagnosis
Embolization, Therapeutic
Female
Gastrointestinal Stromal Tumors - pathology
Gastrointestinal tumors
Humans
Imatinib Mesylate
Liver cancer
Liver Neoplasms - pathology
Liver Neoplasms - secondary
Liver Neoplasms - therapy
Piperazines - therapeutic use
Pyrimidines - therapeutic use
Risk factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Advanced gastrointestinal stromal tumors (GISTs) can metastasize and recur after a long remission period, resulting in serious morbidity, mortality, and complex management issues. A 67-year-old woman presented with epigastric fullness, mild jaundice and weight loss with a history of a bowel resection 7 years prior for a primary GIST of the small bowel. The finding of a heterogeneous mass 15.5 cm in diameter replacing most of the left lobe of the liver by ultrasonography and CT, followed by positive cytological studies revealed a metastatic GIST. Perioperative optimization of the patient's nutritional status along with biliary drainage, and portal vein embolization were performed. Imatinib was successful in reducing the tumor size and facilitating surgical resection. A well-planned multidisciplinary approach should be part of the standard management of advanced or metastatic GIST.
ISSN:1477-7819
1477-7819
DOI:10.1186/1477-7819-6-46