Inhalation of printer-emitted particles impairs cardiac conduction, hemodynamics, and autonomic regulation and induces arrhythmia and electrical remodeling in rats

Using engineered nanomaterial-based toners, laser printers generate aerosols with alarming levels of nanoparticles that bear high bioactivity and potential health risks. Yet, the cardiac impacts of printer-emitted particles (PEPs) are unknown. Inhalation of particulate matter (PM) promotes cardiovas...

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Bibliographic Details
Published in:Particle and fibre toxicology 2020-01, Vol.17 (1), p.7-21, Article 7
Main Authors: Carll, Alex P, Salatini, Renata, Pirela, Sandra V, Wang, Yun, Xie, Zhengzhi, Lorkiewicz, Pawel, Naeem, Nazratan, Qian, Yong, Castranova, Vincent, Godleski, John J, Demokritou, Philip
Format: Article
Language:English
Subjects:
Aerosols
Air Pollutants - toxicity
Air pollution
Anesthesia
Animals
Arrhythmia
Arrhythmias, Cardiac - blood
Arrhythmias, Cardiac - chemically induced
Arrhythmias, Cardiac - urine
Autonomic
Baroreceptors
Biocompatibility
Biological activity
Blood pressure
Cardiac
Cardiac arrhythmia
Cardiovascular diseases
Chronic effects
Conduction
Development and progression
Dopamine
Echocardiography
EKG
Electrocardiogram
Electrocardiography
Electrocardiography - drug effects
Exposure
Health aspects
Health risks
Heart Conduction System - drug effects
Heart failure
Heart rate
Heart Rate - drug effects
Hemodynamics
Hemodynamics - drug effects
Hypertension
Inhalation
Inhalation Exposure - adverse effects
Laser printers
Male
Materials
Morbidity
Morphology
Muscle contraction
Nanomaterials
Nanoparticles
Occupational exposure
Organic chemicals
P waves
Particulate emissions
Particulate matter
Particulate Matter - toxicity
Particulates
Pollutants
Potassium channels (voltage-gated)
Printers
Printing
Protein folding
Rats, Sprague-Dawley
Reflexes
Relaxation time
Respiration
Risk factors
Sensitivity
Standard deviation
Sympathetic Nervous System - drug effects
Systolic pressure
Telemetry
Testing
Toners
Toxicity
Toxicity testing
Trends
Ventricle
Ventricular Pressure - drug effects
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Description
Summary:Using engineered nanomaterial-based toners, laser printers generate aerosols with alarming levels of nanoparticles that bear high bioactivity and potential health risks. Yet, the cardiac impacts of printer-emitted particles (PEPs) are unknown. Inhalation of particulate matter (PM) promotes cardiovascular morbidity and mortality, and ultra-fine particulates (
ISSN:1743-8977
1743-8977
DOI:10.1186/s12989-019-0335-z