Prediction of Mandibular Advancement Device Response Using CPAP Pressure in Different Polysomnographic Phenotypes

Both continuous positive airway pressure (CPAP) pressure and polysomnographic phenotypes have been associated with mandibular advancement device (MAD) treatment response, but the precise relationship has not been fully elucidated. We hypothesized that utilizing CPAP pressure would predict the MAD re...

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Bibliographic Details
Published in:Nature and science of sleep 2022-05, Vol.14, p.517-529
Main Authors: Lee, Chien-Feng, Chen, Yunn-Jy, Huang, Wen-Chi, Hou, Jen-Wen, Liu, Yu-Ting, Shih, Tiffany Ting-Fang, Lee, Pei-Lin, Yu, Chong-Jen
Format: Article
Language:English
Subjects:
Analysis
Care and treatment
Genetic aspects
Original Research
Phenotype
prediction of mad treatment with cpap pressure and polysomnographic phenotype
Sleep apnea syndromes
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Summary:Both continuous positive airway pressure (CPAP) pressure and polysomnographic phenotypes have been associated with mandibular advancement device (MAD) treatment response, but the precise relationship has not been fully elucidated. We hypothesized that utilizing CPAP pressure would predict the MAD response in treatment-naïve patients with moderate-severe obstructive sleep apnea (OSA), and the MAD response would be associated with two polysomnographic phenotypes, including sleep stage dependency and positional dependency. OSA treatment-naïve patients with an apnea-hypopnea index (AHI) ≥15/h who declined CPAP treatment and received MAD treatment for 3-6 months were enrolled. The MAD treatment response was defined as 1) residual AHI under MAD (AHI )
ISSN:1179-1608
1179-1608
DOI:10.2147/NSS.S351027