Atopobium vaginae And Porphyromonas somerae Induce Proinflammatory Cytokines Expression In Endometrial Cells: A Possible Implication For Endometrial Cancer?

The female lower vaginal tract has long been known to have an active microbiota, with Lactobacilli genus representing the prevalent species, and alterations in the vaginal microbiota are known to play a role in different pathological conditions, including bacterial vaginosis, sexually transmitted di...

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Bibliographic Details
Published in:Cancer management and research 2019-09, Vol.11, p.8571-8575
Main Authors: Caselli, Elisabetta, Soffritti, Irene, D'Accolti, Maria, Piva, Isabella, Greco, Pantaleo, Bonaccorsi, Gloria
Format: Article
Language:English
Subjects:
Bacteria
Bacterial vaginosis
Breast cancer
Cancer
Cell culture
Cervical cancer
Cytokines
Development and progression
Endometrial cancer
endometrium
Infertility
inflammatory environment
Medical research
Microbiota
Microbiota (Symbiotic organisms)
Open access publishing
Papillomavirus infections
Research Letter
Sexually transmitted diseases
Technology
Vaginosis
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Summary:The female lower vaginal tract has long been known to have an active microbiota, with Lactobacilli genus representing the prevalent species, and alterations in the vaginal microbiota are known to play a role in different pathological conditions, including bacterial vaginosis, sexually transmitted diseases, HPV persistence, and cervical cancer. By contrast, the uterus was considered sterile until recently, when the advent of next-generation sequencing (NGS) technologies identified a unique uterine microbiota differing from that of the vagina.1 The uterine bacterial load is estimated to be 100–10,000-times lower than that of the vaginal microbiome, and, contrary to the vaginal and cervix microbiota, uterine bacteria grow in mildly alkaline conditions, contrasting to the Lactobacillus-dominated low pH environment of the vagina.2 The microbiota in the uterus can derive from ascension via the cervix, or migrate to the uterus via the haematogenous spread, via the sperm, and other routes (e.g., retrograde spread through the fallopian tubes or gynaecological procedures).1,2 Although the exact role and mechanisms of micro-organisms in the uterus are unclear, recent studies suggest that microbiota could affect uterine receptivity, influencing endometrium fertility.
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S217362