Pathophysiological Relationship between Infections and Systemic Vasculitis

The development of autoimmune disorders requires a combination of genetic, immunological, and environmental factors. Infectious agents, such as viruses and bacteria, can trigger autoimmunity through different mechanisms, and for systemic vasculitis in particular, microbial agents have been suggested...

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Bibliographic Details
Published in:Autoimmune Diseases 2015-01, Vol.2015 (2015), p.12-19
Main Authors: Muñoz-Grajales, Carolina, Pineda, Juan C.
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Autoimmune diseases
Autoimmunity
Bacteria
Communicable diseases
Complications and side effects
Coronary vessels
Deoxyribonucleic acid
Development and progression
DNA
E coli
Environmental factors
Epidemics
Etiology
Genetic aspects
Heat shock proteins
Hepatitis
HIV
Human immunodeficiency virus
Immune response
Immunology
Influenza
Lymphocytes
Medical research
Neutrophils
Peptides
Review
Staphylococcus infections
Systemic vasculitis
Tuberculosis
Vasculitis
Viruses
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Summary:The development of autoimmune disorders requires a combination of genetic, immunological, and environmental factors. Infectious agents, such as viruses and bacteria, can trigger autoimmunity through different mechanisms, and for systemic vasculitis in particular, microbial agents have been suggested to be involved in its pathogenesis. Although the exact mechanisms have not been fully elucidated, different theories have been postulated. This review considers the role of infections in the etiology of primary vasculitis, emphasizing their related immunological events.
ISSN:2090-0430
2090-0422
2090-0430
DOI:10.1155/2015/286783