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Evaluation of Beta-Defensin 1 and Mannose-Binding Lectin 2 Polymorphisms in Children with Dental Caries Compared to Caries-Free Controls: A Systematic Review and Meta-Analysis
: Some variants in ( ) and ( ) genes can be associated with oral diseases. Herein, we designed a systematic review and meta-analysis to evaluate the association of ( , , and ) and ( and ) polymorphisms with the susceptibility to dental caries (DC) in children. : A systematic literature search was co...
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Published in: | Children (Basel) 2023-01, Vol.10 (2), p.232 |
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Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | : Some variants in
(
) and
(
) genes can be associated with oral diseases. Herein, we designed a systematic review and meta-analysis to evaluate the association of
(
,
, and
) and
(
and
) polymorphisms with the susceptibility to dental caries (DC) in children.
: A systematic literature search was conducted in the PubMed/Medline, Web of Science, Scopus, and Cochrane Library databases until 3 December 2022, without any restrictions. The odds ratio (OR), along with a 95% confidence interval (CI) of the effect sizes, are reported. Analyses including a subgroup analysis, a sensitivity analysis, and funnel plot analyses were conducted.
: A total of 416 records were identified among the databases, and nine articles were entered into the meta-analysis. A significant relationship was found between the T allele of
polymorphism and DC susceptibility, and the T allele was related to an elevated risk of DC in children (OR = 1.225; 95%CI: 1.022, 1.469;
= 0.028; I
= 0%). No other polymorphisms were associated with DC. All articles were of moderate quality. Egger's test in homozygous and dominant models demonstrated a significant publication bias for the association of
polymorphism with DC risk.
: The results demonstrated that the T allele of
polymorphism had an elevated risk for DC in children. However, there were only few studies that evaluated this association. |
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ISSN: | 2227-9067 2227-9067 |
DOI: | 10.3390/children10020232 |