Effects of different plasma target concentrations of remifentanil on the MACBAR of sevoflurane in children with laparoscopic surgery

• Published in: BMC anesthesiology 2021-09, Vol.21 (1), p.1-231, Article 231
• Main Authors: Wang, Dan, Xu, Juan, Yang, Xiao-Lin, Guo, Yan-Xia, Jiang, Ping-Ping, Zhang, Guo-Yuan
• Format: Article
• Language: English
• Subjects: Alveoli; Analgesics; Analysis; Anesthesia; Blood pressure; Carbon dioxide; Cardiac arrhythmia; Children; Children & youth; Epinephrine; Hypotension; Laparoscopic surgery; Laparoscopy; Medical personnel; Minimum alveolar concentration (MAC); Narcotics; Noradrenaline; Norepinephrine; Patients; Pediatric anesthesia; Pediatrics; Plasma; Pneumoperitoneum stimulus; Remifentanil; Sevoflurane; Statistical analysis; Surgery; Variance analysis
• ISSN: 1471-2253; 1471-2253
• DOI: 10.1186/s12871-021-01453-z

Background To investigate the effects of different plasma target concentrations of remifentanil on the minimum alveolar concentration (MAC) for blocking adrenergic response (BAR) of sevoflurane in children with laparoscopic herniorrhaphy. Methods Seventy-five children with 3-7 years old scheduled for laparoscopic herniorrhaphy were randomly divided into group R.sub.0, group R.sub.1, and group R.sub.2 according to different remifentanil plasma target concentration (0, 1, and 2 ngml.sup.-1), respectively. The MAC.sub.BAR of sevoflurane was determined by the up-and-down and sequential method in each group. The concentrations of epinephrine and noradrenaline were also determined at corresponding time points. Results A total of 52 child patients were used among the anticipated 75 patients. In groups R.sub.0, R.sub.1, and R.sub.2, the MAC.sub.BAR of sevoflurane was (3.29 [+ or -] 0.17) %, (2.12 [+ or -] 0.10) % and (1.29 [+ or -] 0.11) %, respectively, and a significant difference was found among the three groups (P