Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow

The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison to the batch procedure, while achieving simila...

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Published in:Beilstein journal of organic chemistry 2020-06, Vol.16 (1), p.1305-1312
Main Authors: Nyuchev, Alexander V, Wan, Ting, Cendón, Borja, Sambiagio, Carlo, Struijs, Job J C, Ho, Michelle, Gulías, Moisés, Wang, Ying, Noël, Timothy
Format: Article
Language:English
Subjects:
Chemistry
continuous-flow
c–h functionalization
Experiments
Fluorine
Full Research Paper
Light
organic synthesis
photoredox catalysis
Physiology
trifluoromethoxylation
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cited_by cdi_FETCH-LOGICAL-c475t-17d9cf147362baffed6fa21b44bfd29b7059a2034c6e19ecded5ab503c77c7963
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container_title Beilstein journal of organic chemistry
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creator Nyuchev, Alexander V
Wan, Ting
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Sambiagio, Carlo
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Gulías, Moisés
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Noël, Timothy
description The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison to the batch procedure, while achieving similar or higher yields. In addition, the use of inorganic bases was demonstrated to increase the reaction yield under batch conditions.
doi_str_mv 10.3762/bjoc.16.111
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source Open Access: PubMed Central; Publicly Available Content Database
subjects Chemistry
continuous-flow
c–h functionalization
Experiments
Fluorine
Full Research Paper
Light
organic synthesis
photoredox catalysis
Physiology
trifluoromethoxylation
title Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow
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