Voltammetric behavior of rutin at a boron-doped diamond electrode. Its electroanalytical determination in a pharmaceutical formulation

• Published in: Central European journal of chemistry 2013-10, Vol.11 (10), p.1674-1681
• Main Authors: Pinar, Pinar Talay, Yardim, Yavuz, Senturk, Zuhre
• Format: Article
• Language: English
• Subjects: Accumulations; Adsorptivity; Biochemistry; Biological and Medical Physics; Biophysics; Boron-doped diamond electrode; Buffers; Calibration; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Diamonds; Dietary supplement; Electrodes; Formulations; Geochemistry; Research Article; Rutin; Square-wave adsorptive stripping voltammetry; Stripping; Voltammetry
• ISSN: 1895-1066; 2391-5420; 1644-3624; 2391-5420
• DOI: 10.2478/s11532-013-0292-6

This paper examined for the first time, the possibilities of the usage of a boron-doped diamond electrode for the redox behavior of rutin using cyclic and adsorptive stripping voltammetry. The cyclic voltammograms showed a pair of redox peaks at lower potentials followed by an irreversible oxidation peak at higher positive potential. Using square-wave adsorptive stripping voltammetry, the compound yielded a well-defined voltammetric response in Britton-Robinson buffer, pH 4.0 at +0.48 V ( vs. Ag/AgCl) (after 60 s accumulations at a fixed potential of 0.2 V). The calibration curve was linear in the concentration range from 0.01 µg mL −1 to 0.1 µg mL −1 (1.64×10 −8 M − 1.64×10 −7 M). A detection limit of 0.0017 µg mL −1 (2.78×10 −9 M) was observed without any chemical modifications and electrochemical surface pretreatments. As an example, the practical applicability of boron-doped diamond electrode was tested with the measurement of rutin in dietary supplement products.