Mango leaf tea promotes hepatoprotective effects in obese rats

• Published in: Journal of functional foods 2018-10, Vol.49, p.437-446
• Main Authors: Medina Ramírez, Natalia, de Queiróz, José Humberto, Machado Rocha Ribeiro, Sônia, Lopes Toledo, Renata Celi, Castro Moreira, Maria Eliza, Mafra, Claudio Lisías, dos Anjos Benjamin, Laércio, de Morais Coelho, Camila, Paranho Veloso, Marcia, Stampini Duarte Martino, Hércia
• Format: Article
• Language: English
• Subjects: Hepatic steatosis; Liver histology; Mangifera indica; Molecular docking; NF-κB; PPARα; Stress oxidative
• ISSN: 1756-4646; 2214-9414
• DOI: 10.1016/j.jff.2018.09.010

[Display omitted] •Mango leaf tea suppresses inflammation and hepatic steatosis.•Mango leaf tea decreases fat droplets in liver of obese rats.•Mangiferin has positivity interaction with PPAR-α. As mango leaf tea contains mangiferin and other bioactive compounds, this study investigated its anti-inflammatory, antioxidant and hepatoprotective effects on rats with high-fat induced obesity. Three groups were established: a control group (AIN93M diet), an obese group (high-fat diet HFD) and a treatment group (HFD with mango leaf tea for 8 weeks). Mango leaf tea increased antioxidant enzymes, total antioxidant capacity, AdipoR2 and PPAR-α mRNA and proteins expressions and, it also inhibited the NF-κB p65 and SREBP1c genes expressions in the liver. This beverage also leads to Cpt1 overexpression and a significant decrease in the accumulation of fat droplets, improving the hepatic steatosis. Molecular docking suggested a positive interaction between mangiferin, the main bioactive compound of mango leaf tea, and PPAR-α. Mango leaf tea exhibited a hepatoprotective effect through activating PPARα and decreasing the NF-κB p65 expressions, reducing oxidative stress and steatosis, and improving the lipid metabolism.