Gastrointestinal morphological alterations in obese rats kept under hypercaloric diets

Hypercaloric diets have been successfully used as experimental models of obesity. This work compared morphological characteristics of inferior gastrointestinal organs. The experiment lasted 10 weeks, during which the rats' food consumption, body weight, distance between the mouth and neck, dist...

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Bibliographic Details
Published in:International journal of general medicine 2013-01, Vol.6 (default), p.479-488
Main Authors: Nascimento, Raphael Castiglioni, Mabel, Haryanne, Queiroz, Bruna Nunes, Paresque, Roberta
Format: Article
Language:English
Subjects:
Abdomen
gastrointestinal morphology
hypercaloric diet
diet-induced obesity
Gastrointestinal system
Health aspects
Ketogenic diet
Medical research
Medicine, Experimental
Morphology
Original Research
Physiological aspects
Rodents
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Summary:Hypercaloric diets have been successfully used as experimental models of obesity. This work compared morphological characteristics of inferior gastrointestinal organs. The experiment lasted 10 weeks, during which the rats' food consumption, body weight, distance between the mouth and neck, distance between mouth and neck, distance between neck and tail, and abdominal circumference were evaluated weekly. After the sacrifice of the rats, 20 variables referring to inferior gastrointestinal morphology were assessed. The results comprised descriptive statistics of the data, analysis of main components, linear correlation, and t-tests. Significant differences were found between the two groups for the variables of abdominal circumference, retroperitoneal fat, ratio between retroperitoneal fat/animal weight, stomach weight, ratio between animal weight/intestine weight and mesentery/animal weight, length of small intestine, length of large intestine, and lateral line of the cecum. The data allow us to state that a hypercaloric diet can be responsible an increase in fat in the abdominal cavity as well as gastrointestinal morphological alterations, principally in stomach development.
ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S35482