Polymeric worm-like nanomicellar system for accelerated wound healing

Self-assembly is an unparalleled step in designing macromolecular analogs of nature's simple amphiphiles. Tailoring hydrogel systems - a material with ample potential for wound healing applications - to simultaneously alleviate infection and prompt wound closure is vastly appealing. The poly (D...

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Bibliographic Details
Published in:Journal of advanced pharmaceutical technology and research 2020-01, Vol.11 (1), p.36-43
Main Authors: Singh, Aarti, Shakeel, Adeeba, Kochhar, Dakshi, Jeevanandham, Sampathkumar, Rajput, Satyendra, Mukherjee, Monalisa
Format: Article
Language:English
Subjects:
Aggregates
Animals
Anti-inflammatory agents
block copolymers
Dermis
Equilibrium
Exudates
Homeostasis
hydrogel
Hydrogels
Immunology
Inflammation
Macromolecules
Microscopy
Morphology
Nature
Original
Polymers
Pore size
Porosity
Povidone
Self-assembly
Tumor necrosis factor-TNF
Wound care
Wound healing
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Summary:Self-assembly is an unparalleled step in designing macromolecular analogs of nature's simple amphiphiles. Tailoring hydrogel systems - a material with ample potential for wound healing applications - to simultaneously alleviate infection and prompt wound closure is vastly appealing. The poly (DEAEMA-co-AAc) (PDEA) is examined with a cutaneous excisional wound model alterations in wound size, and histological assessments revealed a higher wound healing rate, including dermis proliferation, re-epithelialization, reduced scar formation, and anti-inflammatory properties. Moreover, a mechanism for the formation of spherical and worm-like micelles (WLMs) is delineated using a suite of characterizations. The excellent porosity and ability to absorb exudates impart the PDEA with reliable wound healing. Altogether, this system demonstrates exceptional promise as an infection-mitigating, cell-stimulating, homeostasis-maintaining dressing for accelerated wound healing. The aim and objective of this study is to understand the mechanism of self-assembly in synthesized WLMs from PDEA and their application in wound healing.
ISSN:2231-4040
0976-2094
DOI:10.4103/japtr.JAPTR_153_19