Evaluating the Efficacy of Probiotics in IBS Treatment Using a Systematic Review of Clinical Trials and Multi-Criteria Decision Analysis

The evaluation of probiotics' efficacy in treating irritable bowel syndrome is supported by an increasing number of clinical studies based on a heterogeneous approach of products tested and the patient cohort involved. Although the role of gut microbiota dysbiosis in IBS pathogenesis and the be...

Full description

Saved in:
Bibliographic Details
Published in:Nutrients 2022-06, Vol.14 (13), p.2689
Main Authors: Ceccherini, Cecilia, Daniotti, Sara, Bearzi, Claudia, Re, Ilaria
Format: Article
Language:English
Subjects:
Abdomen
Bifidobacterium animalis
Clinical trials
Constipation
Decision making
Decision Support Techniques
Dysbacteriosis
Functional foods & nutraceuticals
Humans
Intestinal microflora
Irritable bowel syndrome
Irritable Bowel Syndrome - drug therapy
Lacticaseibacillus rhamnosus
Lactobacilli
Lactobacillus acidophilus
Lactobacillus rhamnosus
Literature reviews
Meta-analysis
Microbiota
microbiota dysbiosis
Multiple criterion
nutraceuticals
Pain
Pathogenesis
Patients
Prebiotics
Precision medicine
Probiotics
Probiotics - therapeutic use
Qualitative analysis
Quality of Life
selective efficacy
Systematic review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The evaluation of probiotics' efficacy in treating irritable bowel syndrome is supported by an increasing number of clinical studies based on a heterogeneous approach of products tested and the patient cohort involved. Although the role of gut microbiota dysbiosis in IBS pathogenesis and the beneficial contribution of probiotics were demonstrated, a tool to discriminate symptom-specific strains and a personalised medicine protocol are still lacking. Thus, this study employs, for the first time, a method that combines the preferred reporting items for systematic reviews and meta-analysis and multi-criteria decision analysis methods in a structured decision-making tool to analyze the efficacy of probiotic mix, in order to identify the most effective formulation and to discriminate which probiotics are more efficient in treating different symptoms. The PRISMA methodology resulted in a qualitative and quantitative analysis of 104 clinical studies from 2011 to 2021, revealing a prevalence of , and subsp. . MCDA analysis showed that formulations based on and have the highest efficacy, especially on quality of life, bloating, and abdominal pain. This methodological approach could become more specific by modelling clinical studies according to the age and gender of patients and probiotic strain.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14132689