Effects of a wholegrain-rich diet on markers of colonic fermentation and bowel function and their associations with the gut microbiome: a randomised controlled cross-over trial

Diets rich in whole grains are associated with health benefits. Yet, it remains unclear whether the benefits are mediated by changes in gut function and fermentation. We explored the effects of whole-grain vs. refined-grain diets on markers of colonic fermentation and bowel function, as well as thei...

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Published in:Frontiers in nutrition (Lausanne) 2023-06, Vol.10, p.1187165-1187165
Main Authors: Procházková, Nicola, Venlet, Naomi, Hansen, Mathias L, Lieberoth, Christian B, Dragsted, Lars Ove, Bahl, Martin I, Licht, Tine Rask, Kleerebezem, Michiel, Lauritzen, Lotte, Roager, Henrik M
Format: Article
Language:English
Subjects:
colonic transit time
dietary fibres
energy harvest
gut microbiota
Nutrition
refined-grain diet
whole-grain diet
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Summary:Diets rich in whole grains are associated with health benefits. Yet, it remains unclear whether the benefits are mediated by changes in gut function and fermentation. We explored the effects of whole-grain vs. refined-grain diets on markers of colonic fermentation and bowel function, as well as their associations with the gut microbiome. Fifty overweight individuals with increased metabolic risk and a high habitual intake of whole grains (~69 g/day) completed a randomised cross-over trial with two 8-week dietary intervention periods comprising a whole-grain diet (≥75 g/day) and a refined-grain diet (
ISSN:2296-861X
2296-861X
DOI:10.3389/fnut.2023.1187165