Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study

It is established that patients hospitalised with COVID-19 often have ongoing morbidity affecting activity of daily living (ADL), employment, and mental health. However, little is known about the relative outcomes in patients with COVID-19 neurological or psychiatric complications. We conducted a UK...

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Published in:Scientific reports 2025-01, Vol.15 (1), p.3443-14, Article 3443
Main Authors: Shil, Rajish S. K., Seed, Adam, Franklyn, Nkongho Egbe, Sargent, Brendan F., Wood, Greta K., Huang, Yun, Dodd, Katherine C., Lilleker, James B., Pollak, Thomas A., Defres, Sylviane, Jenkins, Thomas M., Davies, Nicholas W. S., Cousins, David A., Zandi, Michael S., Jackson, Thomas A., Benjamin, Laura A., Easton, Ava, Solomon, Tom, Bradley, John R., Chinnery, Patrick F., Smith, Craig J., Nicholson, Timothy R., Carson, Alan, Thomas, Rhys H., Ellul, Mark Alexander, Wood, Nicholas W., Breen, Gerome, Michael, Benedict Daniel
Format: Article
Language:English
Subjects:
692/617/375/1367
692/617/375/1370/534
Activities of Daily Living
Adult
Aged
Angiotensin
Angiotensin-converting enzyme inhibitors
Case studies
Case-Control Studies
COVID-19
COVID-19 - complications
COVID-19 - epidemiology
COVID-19 - psychology
Employment
Female
Humanities and Social Sciences
Humans
Hypertension
Male
Mental depression
Mental Disorders - epidemiology
Mental Disorders - etiology
Middle Aged
Morbidity
multidisciplinary
Nervous System Diseases - epidemiology
Nervous System Diseases - etiology
Neurological complications
Peptidyl-dipeptidase A
SARS-CoV-2
Science
Science (multidisciplinary)
Statins
United Kingdom - epidemiology
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Summary:It is established that patients hospitalised with COVID-19 often have ongoing morbidity affecting activity of daily living (ADL), employment, and mental health. However, little is known about the relative outcomes in patients with COVID-19 neurological or psychiatric complications. We conducted a UK multicentre case–control study of patients hospitalised with COVID-19 (controls) and those who developed COVID-19 associated acute neurological or psychiatric complications (cases). Among the 651 patients, [362 (55%) cases and 289 (45%) controls], a higher proportion of cases had impairment in ADLs (199 [68.9%] vs 101 [51.8%], OR 2.06, p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-80833-0