Serotonergic Antidepressants and Risk for Traumatic Intracranial Bleeding

Background: Serotonergic antidepressants may predispose to bleeding but the effect on traumatic intracranial bleeding is unknown. Methods: The rate of intracranial bleeding in patients with antidepressant medication was compared to patients not antidepressants in a cohort of patients with acute head...

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Bibliographic Details
Published in:Frontiers in neurology 2021-10, Vol.12, p.758707-758707
Main Authors: Isokuortti, Harri, Iverson, Grant L., Posti, Jussi P., Ruuskanen, Jori O., Brander, Antti, Kataja, Anneli, Nikula, Milaja, Öhman, Juha, Luoto, Teemu M.
Format: Article
Language:English
Subjects:
anticoagulation
antidepressant agents
antithrombotic agents (MeSH)
brain injuries
intracranial hemorrhages
Neurology
traumatic
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Summary:Background: Serotonergic antidepressants may predispose to bleeding but the effect on traumatic intracranial bleeding is unknown. Methods: The rate of intracranial bleeding in patients with antidepressant medication was compared to patients not antidepressants in a cohort of patients with acute head injury. This association was examined by using a consecutive cohort of head trauma patients from a Finnish tertiary center emergency department (Tampere University Hospital, Tampere, Finland). All consecutive (2010–2012) adult patients ( n = 2,890; median age = 58; male = 56%, CT-positive = 22%, antithrombotic medication users = 25%, antidepressant users = 10%) who underwent head CT due to head trauma in the emergency department were included. Results: Male gender, GCS
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2021.758707