Chronic Supplementation of 2S-Hesperidin Improves Acid-Base Status and Decreases Lactate at FatMax, at Ventilatory Threshold 1 and 2 and after an Incremental Test in Amateur Cyclists

Chronic supplementation with 2S-hesperidin improves performance; however, the mechanisms underlying this effect have not yet been explored. Therefore, the aim of this study was to assess whether changes in acid-base status may be associated with improved performance after 2S-hesperidin supplementati...

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Published in:Biology (Basel, Switzerland) Switzerland), 2022-05, Vol.11 (5), p.736
Main Authors: Martínez-Noguera, Francisco Javier, Alcaraz, Pedro E, Carlos-Vivas, Jorge, Marín-Pagán, Cristian
Format: Article
Language:English
Subjects:
Acid-base status
Acidification
Acids
Antioxidants
Bicycling
Blood
Carbohydrate metabolism
Carbon dioxide
Chronic illnesses
Citrus fruits
Diet
endurance
exercise
Exercise intensity
Flavonoids
Hesperidin
Inflammation
Lactic acid
Lipid metabolism
Medical laboratories
Metabolism
Metabolites
Nitric oxide
Nutrition research
Placebos
Polyphenols
sport nutrition
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Summary:Chronic supplementation with 2S-hesperidin improves performance; however, the mechanisms underlying this effect have not yet been explored. Therefore, the aim of this study was to assess whether changes in acid-base status may be associated with improved performance after 2S-hesperidin supplementation compared to microcellulose (placebo). Forty amateur cyclists (n = 20 per group) underwent a rectangular test where capillary blood samples were taken at baseline, FatMax1, VT1, VT2, P , FatMax2 and EPOC to measure acid-base parameters. After eight weeks of 2S-hesperidin supplementation (500 mg/d) increased HCO , SBC, ABE ( ≤ 0.05) and decreased Lac were found at FatMax1, VT1, FatMax2 and EPOC ( ≤ 0.05), while decreased Lac at VT2 was found with a large effect size (ES = 1.15) compared to placebo. Significant group differences in the area under the curve were observed when comparing pre-post-intervention pH changes ( = 0.02) between groups. Chronic supplementation with 2S-hesperidin improved acid-base status and Lac, both at low-moderate and submaximal intensities, improving recovery after exercise-to-exhaustion in amateur cyclists.
ISSN:2079-7737
2079-7737
DOI:10.3390/biology11050736