Prevalence and risk factors for psychotic symptoms in young, first-episode and drug-naïve patients with major depressive disorder

Major depressive disorder (MDD) is a common psychiatric disorder worldwide. Psychotic depression has been reported to be frequently under-diagnosed due to poor recognition of psychotic features. Therefore, the purpose of this study was to reveal the rate and risk factors of psychotic symptoms in you...

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Bibliographic Details
Published in:BMC psychiatry 2024-01, Vol.24 (1), p.66-10, Article 66
Main Authors: Wu, Yuxuan, Zhao, Xueli, Li, Zhe, Yang, Ruchang, Peng, Ruijie, Zhou, Yue, Xia, Xingzhi, Deng, Hanxu, Zhang, Xiaobin, Du, Xiangdong, Zhang, Xiangyang
Format: Article
Language:English
Subjects:
Anxiety
Blood pressure
Care and treatment
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Depressive Disorder, Major
Diagnosis
Epidemiology
First-episode psychosis
Health aspects
Health risks
High density lipoprotein
Humans
Low density lipoprotein
Major depressive disorder
Mental depression
Mental disorders
Prevalence
Psychological aspects
Psychological manifestations of general diseases
Psychosis
Psychotic symptoms
Risk Factors
Social aspects
Suicide
Suicides & suicide attempts
Thyroid hormones
Thyroid-stimulating hormone
Thyrotropin
Thyroxine
Triglycerides
Triiodothyronine
Young Adult
Young adults
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Summary:Major depressive disorder (MDD) is a common psychiatric disorder worldwide. Psychotic depression has been reported to be frequently under-diagnosed due to poor recognition of psychotic features. Therefore, the purpose of this study was to reveal the rate and risk factors of psychotic symptoms in young, drug-naïve patients with major depressive disorder at the time of their first episode. A total of 917 patients were recruited and divided into psychotic and non-psychotic subgroups based on the Positive and Negative Syndrome Scale (PANSS) positive subscale score. Anxiety symptoms and depressive symptoms were measured by the Hamilton Anxiety Rating Scale (HAMA) and the 17-item Hamilton Depression Rating Scale (HAMD-17), respectively. Several biochemical indicators such as total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were also measured. The rate of psychotic symptoms among young adult MDD patients was 9.1%. There were significant differences in TSH (p
ISSN:1471-244X
1471-244X
DOI:10.1186/s12888-024-05517-5