Supplementation of Heat-Treated Lactiplantibacillus plantarum nF1 Changes the Production of Short-Chain Fatty Acids in Healthy Infants

Background. Imbalance of the gut microbiome and decrease in the number of short-chain fatty acid (SCFA)-producing bacteria often affect human health by altering intestinal and immune homeostasis. The use of probiotics has been shown to be an attractive method to modulate gut microbiota to prevent or...

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Bibliographic Details
Published in:Journal of nutrition and metabolism 2024-04, Vol.2024, p.5558566-8
Main Authors: Kwon, Yoowon, Cho, Kee Hyun, Ma, Sangbae, Ko, Hyelyun, Hong, Geun-Hye, Lee, So-Young, Park, Kun-Young, Chung, Jin A., Jeong, Su Jin
Format: Article
Language:English
Subjects:
Acetates
Acetic acid
Amino acids
Birth weight
Chromatography
Digestive system
Dysbacteriosis
Esters
Fatty acids
Feces
Gastrointestinal tract
Heat
Homeostasis
Infants
Intestinal microflora
Intestine
Lactiplantibacillus plantarum
Metabolism
Metabolites
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Probiotics
Questionnaires
Supplements
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Summary:Background. Imbalance of the gut microbiome and decrease in the number of short-chain fatty acid (SCFA)-producing bacteria often affect human health by altering intestinal and immune homeostasis. The use of probiotics has been shown to be an attractive method to modulate gut microbiota to prevent or treat intestinal dysbiosis. Likewise, this study aimed to determine whether the oral consumption of heat-treated Lactiplantibacillus plantarum nF1 (HLp-nF1) induces changes in the gut environment in healthy infants by measuring changes in fecal SCFAs. Methods. The study enrolled 43 infants aged under 2 months, with 30 infants in the HLp-nF1 group receiving HLp-nF1 orally (2.5 × 1010 cells/g/pack, daily dose of two packs) for 8 weeks. The fecal samples were collected and the questionnaires were administered at weeks 0 and 8. Results. The concentrations of the total SCFAs, acetate, propionate, and butyrate significantly increased following HLp-nF1 supplementation (P
ISSN:2090-0724
2090-0732
DOI:10.1155/2024/5558566