SPOC: a widely distributed domain associated with cancer, apoptosis and transcription

The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) domain. The aim of this study is to characterize the family at the sequence level. We describe undetected members of the Spen family i...

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Bibliographic Details
Published in:BMC bioinformatics 2004-07, Vol.5 (1), p.91-91, Article 91
Main Authors: Sánchez-Pulido, Luis, Rojas, Ana M, van Wely, Karel H, Martinez-A, Carlos, Valencia, Alfonso
Format: Article
Language:English
Subjects:
Amino Acid Sequence - genetics
Animals
Apoptosis - genetics
Arabidopsis Proteins - chemistry
Arabidopsis Proteins - genetics
Caenorhabditis elegans Proteins - chemistry
Caenorhabditis elegans Proteins - genetics
Conserved Sequence - genetics
Drosophila Proteins - chemistry
Drosophila Proteins - genetics
Humans
Molecular Sequence Data
Neoplasms - genetics
Peptides - chemistry
Peptides - genetics
Plasmodium - genetics
Protein Structure, Tertiary - genetics
Proteins - chemistry
Proteins - genetics
Protozoan Proteins - chemistry
Protozoan Proteins - genetics
Saccharomyces cerevisiae Proteins - chemistry
Saccharomyces cerevisiae Proteins - genetics
Sequence Homology, Amino Acid
Signal Recognition Particle - genetics
Transcription, Genetic - genetics
Xenopus Proteins - chemistry
Xenopus Proteins - genetics
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Summary:The Split ends (Spen) family are large proteins characterised by N-terminal RNA recognition motifs (RRMs) and a conserved SPOC (Spen paralog and ortholog C-terminal) domain. The aim of this study is to characterize the family at the sequence level. We describe undetected members of the Spen family in other lineages (Plasmodium and Plants) and localise SPOC in a new domain context, in a family that is common to all eukaryotes using profile-based sequence searches and structural prediction methods. The widely distributed DIO (Death inducer-obliterator) family is related to cancer and apoptosis and offers new clues about SPOC domain functionality.
ISSN:1471-2105
1471-2105
DOI:10.1186/1471-2105-5-91