Emerging Biosensing Technologies towards Early Sepsis Diagnosis and Management

Sepsis is defined as a systemic inflammatory dysfunction strictly associated with infectious diseases, which represents an important health issue whose incidence is continuously increasing worldwide. Nowadays, sepsis is considered as one of the main causes of death that mainly affects critically ill...

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Published in:Biosensors (Basel) 2022-10, Vol.12 (10), p.894
Main Authors: Bonini, Andrea, Carota, Angela Gilda, Poma, Noemi, Vivaldi, Federico Maria, Biagini, Denise, Bottai, Daria, Lenzi, Alessio, Tavanti, Arianna, Di Francesco, Fabio, Lomonaco, Tommaso
Format: Article
Language:English
Subjects:
Bacterial infections
Biomarkers
Biosensors
Care and treatment
Diagnosis
diagnostic
electrochemical biosensors
Electrochemistry
Health aspects
Infectious diseases
Inflammation
Laboratories
Mortality
Multiple organ failure
optical biosensors
Prevention
Response time
Review
Risk factors
Sepsis
sepsis biomarkers
System effectiveness
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Summary:Sepsis is defined as a systemic inflammatory dysfunction strictly associated with infectious diseases, which represents an important health issue whose incidence is continuously increasing worldwide. Nowadays, sepsis is considered as one of the main causes of death that mainly affects critically ill patients in clinical settings, with a higher prevalence in low-income countries. Currently, sepsis management still represents an important challenge, since the use of traditional techniques for the diagnosis does not provide a rapid response, which is crucial for an effective infection management. Biosensing systems represent a valid alternative due to their characteristics such as low cost, portability, low response time, ease of use and suitability for point of care/need applications. This review provides an overview of the infectious agents associated with the development of sepsis and the host biomarkers suitable for diagnosis and prognosis. Special focus is given to the new emerging biosensing technologies using electrochemical and optical transduction techniques for sepsis diagnosis and management.
ISSN:2079-6374
2079-6374
DOI:10.3390/bios12100894