The Potential Adjuvanticity of CAvant®SOE for Foot-and-Mouth Disease Vaccine

Foot-and-mouth disease (FMD) is a notifiable contagious disease of cloven-hoofed mammals. A high potency vaccine that stimulates the host immune response is the foremost strategy used to prevent disease persistence in endemic regions. FMD vaccines comprise inactivated virus antigens whose immunogeni...

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Bibliographic Details
Published in:Vaccines (Basel) 2021-09, Vol.9 (10), p.1091
Main Authors: Ahn, Young-Hoon, Chathuranga, W. A. Gayan, Shim, Young-Jung, Haluwana, D. K., Kim, Eun-Hee, Yoon, In-Joong, Lim, Yong-Taik, Shin, Sung Ho, Jo, Hyundong, Hwang, Seong Yun, Kim, Hyun Mi, Lee, Min Ja, Park, Jong-Hyeon, Yoo, Sung-Sik, Lee, Jong-Soo
Format: Article
Language:English
Subjects:
adjuvant
Adjuvanticity
Adjuvants
Aluminum
Antibodies
Antigens
CAvant®SOE
Communication
Deactivation
Foot & mouth disease
foot-and-mouth disease virus
Hogs
Immune response
Immune response (cell-mediated)
Immune system
Immunization
Immunogenicity
Immunoglobulin G
Interleukin 4
Peptides
Signs and symptoms
vaccine
Vaccines
Viruses
water-in-oil emulsion
γ-Interferon
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Summary:Foot-and-mouth disease (FMD) is a notifiable contagious disease of cloven-hoofed mammals. A high potency vaccine that stimulates the host immune response is the foremost strategy used to prevent disease persistence in endemic regions. FMD vaccines comprise inactivated virus antigens whose immunogenicity is potentiated by immunogenic adjuvants. Oil-based adjuvants have clear advantages over traditional adjuvant vaccines; however, there is potential to develop novel adjuvants to increase the potency of FMD vaccines. Thus, we aimed to evaluate the efficacy of a novel water-in-oil emulsion, called CAvant®SOE, as a novel vaccine adjuvant for use with inactivated FMD vaccines. In this study, we found that inactivated A22 Iraq virus plus CAvant®SOE (iA22 Iraq-CAvant®SOE) induced effective antigen-specific humoral (IgG, IgG1, and IgG2a) and cell-mediated immune responses (IFN-γ and IL-4) in mice. Immunization of pigs with a single dose of iA22 Iraq-CAvant®SOE also elicited effective protection, with no detectable clinical symptoms against challenge with heterologous A/SKR/GP/2018 FMDV. Levels of protection are strongly in line with vaccine-induced neutralizing antibody titers. Collectively, these results indicate that CAvant®SOE-adjuvanted vaccine is a promising candidate for control of FMD in pigs.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines9101091