Chitin, chitosan, and its derivatives for wound healing: old and new materials

Chitin (β-(1-4)-poly-N-acetyl-D-glucosamine) is widely distributed in nature and is the second most abundant polysaccharide after cellulose. It is often converted to its more deacetylated derivative, chitosan. Previously, many reports have indicated the accelerating effects of chitin, chitosan, and...

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Bibliographic Details
Published in:Journal of functional biomaterials 2015-03, Vol.6 (1), p.104-142
Main Authors: Azuma, Kazuo, Izumi, Ryotaro, Osaki, Tomohiro, Ifuku, Shinsuke, Morimoto, Minoru, Saimoto, Hiroyuki, Minami, Saburo, Okamoto, Yoshiharu
Format: Article
Language:English
Subjects:
adhesive
animal experiments
Biomaterials
Biomedical materials
Chitin
chitin nanofiber
Chitosan
chitosan nanofiber
Derivatives
Nanostructure
Review
Surgical implants
Wound healing
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Summary:Chitin (β-(1-4)-poly-N-acetyl-D-glucosamine) is widely distributed in nature and is the second most abundant polysaccharide after cellulose. It is often converted to its more deacetylated derivative, chitosan. Previously, many reports have indicated the accelerating effects of chitin, chitosan, and its derivatives on wound healing. More recently, chemically modified or nano-fibrous chitin and chitosan have been developed, and their effects on wound healing have been evaluated. In this review, the studies on the wound-healing effects of chitin, chitosan, and its derivatives are summarized. Moreover, the development of adhesive-based chitin and chitosan are also described. The evidence indicates that chitin, chitosan, and its derivatives are beneficial for the wound healing process. More recently, it is also indicate that some nano-based materials from chitin and chitosan are beneficial than chitin and chitosan for wound healing. Clinical applications of nano-based chitin and chitosan are also expected.
ISSN:2079-4983
2079-4983
DOI:10.3390/jfb6010104