Integrative multiomics analysis of Premolis semirufa caterpillar venom in the search for molecules leading to a joint disease

The joint disease called pararamosis is an occupational disease caused by accidental contact with bristles of the caterpillar Premolis semirufa . The chronic inflammatory process narrows the joint space and causes alterations in bone structure and cartilage degeneration, leading to joint stiffness....

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Bibliographic Details
Published in:Scientific reports 2021-01, Vol.11 (1), p.1995-15, Article 1995
Main Authors: Pidde, Giselle, Nishiyama, Milton Y., de Oliveira, Ursula Castro, Villas-Boas, Isadora M., Paes-Leme, Adriana F., Junqueira-de-Azevedo, Inácio L., Marques-Porto, Rafael, Squaiella-Baptistão, Carla C., Tambourgi, Denise V.
Format: Article
Language:English
Subjects:
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Arthritis
Biopsy
Bristles
Cartilage diseases
Degeneration
Disease
Homology
Humanities and Social Sciences
Inflammation
Joint diseases
multidisciplinary
Occupational diseases
Osteoarthritis
Premolis semirufa
Proteins
Rheumatoid arthritis
Science
Science (multidisciplinary)
Toxins
Venom
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Summary:The joint disease called pararamosis is an occupational disease caused by accidental contact with bristles of the caterpillar Premolis semirufa . The chronic inflammatory process narrows the joint space and causes alterations in bone structure and cartilage degeneration, leading to joint stiffness. Aiming to determine the bristle components that could be responsible for this peculiar envenomation, in this work we have examined the toxin composition of the caterpillar bristles extract and compared it with the differentially expressed genes (DEGs) in synovial biopsies of patients affected with rheumatoid arthritis (RA) and osteoarthritis (OA). Among the proteins identified, 129 presented an average of 63% homology with human proteins and shared important conserved domains. Among the human homologous proteins, we identified seven DEGs upregulated in synovial biopsies from RA or OA patients using meta-analysis. This approach allowed us to suggest possible toxins from the pararama bristles that could be responsible for starting the joint disease observed in pararamosis. Moreover, the study of pararamosis, in turn, may lead to the discovery of specific pharmacological targets related to the early stages of articular diseases.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-79769-y