Investigating cortical hypoxia in multiple sclerosis via time‐domain near‐infrared spectroscopy

• Published in: Annals of clinical and translational neurology 2024-09, Vol.11 (9), p.2372-2381
• Main Authors: Williams, Thomas, Lange, Frédéric, Smith, Kenneth J., Tachtsidis, Ilias, Chataway, Jeremy
• Format: Article
• Language: English
• Subjects: Adult; Case-Control Studies; Cross-Sectional Studies; Data collection; Female; Hemoglobin; Humans; Hypoxia; Hypoxia, Brain - diagnostic imaging; Hypoxia, Brain - metabolism; Magnetic Resonance Imaging; Male; Medical history; Middle Aged; Multiple sclerosis; Multiple Sclerosis, Chronic Progressive - diagnostic imaging; Multiple Sclerosis, Chronic Progressive - metabolism; Oxygen saturation; Prefrontal Cortex - diagnostic imaging; Prefrontal Cortex - metabolism; Propagation; Sensors; Spectroscopy, Near-Infrared - methods; Spectrum analysis; Variables
• ISSN: 2328-9503; 2328-9503
• DOI: 10.1002/acn3.52150

Objectives Hypoperfusion and tissue hypoxia have been implicated as contributory mechanisms in the neuropathology of multiple sclerosis (MS). Our objective has been to study cortical oxygenation in vivo in patients with MS and age‐matched controls. Methods A custom, multiwavelength time‐domain near‐infrared spectroscopy system was developed for assessing tissue hypoxia from the prefrontal cortex. A cross‐sectional case–control study was undertaken assessing patients with secondary progressive MS (SPMS) and age‐matched controls. Co‐registered magnetic resonance imaging was used to verify the location from which near‐infrared spectroscopy data were obtained through Monte Carlo simulations of photon propagation. Additional clinical assessments of MS disease severity were carried out by trained neurologists. Linear mixed effect models were used to compare cortical oxygenation between cases and controls, and against measures of MS severity. Results Thirty‐three patients with secondary progressive MS (median expanded disability status scale 6 [IQR: 5–6.5]; median age 53.0 [IQR: 49–58]) and 20 age‐matched controls were recruited. Modeling of photon propagation confirmed spectroscopy data were obtained from the prefrontal cortex. Patients with SPMS had significantly lower cortical hemoglobin oxygenation compared with controls (−6.0% [95% CI: −10.0 to −1.9], P = 0.004). There were no significant associations between cortical oxygenation and MS severity. Interpretation Using an advanced, multiwavelength time‐domain near‐infrared spectroscopy system, we demonstrate that patients with SPMS have lower cortical oxygenation compared with controls.