Bifunctional, Copper-Doped, Mesoporous Silica Nanosphere-Modified, Bioceramic Scaffolds for Bone Tumor Therapy

• Published in: Frontiers in chemistry 2020-12, Vol.8, p.610232-610232
• Main Authors: Ma, Hongshi, Ma, Zhenjiang, Chen, Qufei, Li, Wentao, Liu, Xiangfei, Ma, Xiaojun, Mao, Yuanqing, Yang, Han, Ma, Hui, Wang, Jinwu
• Format: Article
• Language: English
• Subjects: 3D printing; bifunctional scaffolds; Chemistry; Cu-containing mesoporous silica nanospheres; photothermal tumor therapy; tissue regeneration
• ISSN: 2296-2646; 2296-2646
• DOI: 10.3389/fchem.2020.610232

In the traditional surgical intervention procedure, residual tumor cells may potentially cause tumor recurrence. In addition, large bone defects caused by surgery are difficult to self-repair. Thus, it is necessary to design a bioactive scaffold that can not only kill residual tumor cells but also promote bone defect regeneration simultaneously. Here, we successfully developed Cu-containing mesoporous silica nanosphere-modified β-tricalcium phosphate (Cu-MSN-TCP) scaffolds, with uniform and dense nanolayers with spherical morphology 3D printing and spin coating. The scaffolds exhibited coating time- and laser power density-dependent photothermal performance, which favored the effective killing of tumor cells under near-infrared laser irradiation. Furthermore, the prepared scaffolds favored the proliferation and attachment of rabbit bone marrow-derived mesenchymal stem cells and stimulated the gene expression of osteogenic markers. Overall, Cu-MSN-TCP scaffolds can be considered for complete eradication of residual bone tumor cells and simultaneous healing of large bone defects, which may provide a novel and effective strategy for bone tumor therapy. In the future, such Cu-MSN-TCP scaffolds may function as carriers of anti-cancer drugs or immune checkpoint inhibitors in chemo-/photothermal or immune-/photothermal therapy of bone tumors, favoring for effective treatment.