Prevalence and Residual Risk of HIV in Volunteer Blood Donors of Zhejiang Province, China, from 2018 to 2022

Background. Blood safety levels have been significantly improved since the implementation of nucleic acid amplification technology (NAT) testing for blood donors. However, there remains a residual risk of transfusion transmission infections. This study aimed to evaluate the prevalence of HIV and its...

Full description

Saved in:
Bibliographic Details
Published in:The Canadian journal of infectious diseases & medical microbiology 2024-05, Vol.2024, p.4749097-9
Main Authors: Zhu, Hong, Ding, Wei, Han, Wenjuan, Zheng, Xiaofan, Hu, Yiqing, Dong, Jie, Wu, Yaling, Wu, Danxiao, Liu, Jinhui, Zhu, Faming
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Age
AIDS
Antibodies
Antigens
Blood & organ donations
Blood banks
Blood donors
Blood levels
Blood transfusion
Blood transfusions
Disease control
Disease prevention
Disease transmission
Enzyme-linked immunosorbent assay
Enzymes
Health aspects
Hepatitis B
Hepatitis C
HIV
HIV (Viruses)
HIV antibodies
HIV infection
Human immunodeficiency virus
Infection
Infections
Medical research
Medicine, Experimental
Nucleic acids
Prevalence studies (Epidemiology)
Risk
Risk factors
RNA
Statistical analysis
Statistics
Transfusion
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. Blood safety levels have been significantly improved since the implementation of nucleic acid amplification technology (NAT) testing for blood donors. However, there remains a residual risk of transfusion transmission infections. This study aimed to evaluate the prevalence of HIV and its residual risk transmission among volunteer blood donors of Zhejiang Province, China, for five years after NAT implementation. Materials and Methods. All specimens and information were collected from voluntary unpaid donors at all blood services in Zhejiang Province, China, from January 2018 to December 2022. The HIV antibody or antigen and HIV RNA were detected using enzyme-linked immunosorbent assay and NAT, respectively. The HIV residual risk transmission was calculated using the incidence or window period model. Results. A total of 3,375,678 voluntary blood donors were detected, revealing an HIV prevalence of 9.92/100000. The HIV prevalence of blood donors in 12 blood services in Zhejiang Province was 6.11, 6.98, 7.45, 8.21, 8.36, 8.94, 9.04, 9.66, 9.73, 10.22, 11.80, and 12.47 per 100000 donors, without statistically significant difference observed among the services (p>0.05). The HIV prevalence of males (15.49/100000) was significantly higher compared to females (1.95/100000; p0.05), but the HIV prevalence in the 26–35 age group and 18–25 age group was significantly higher compared to the 36–45 age group (p
ISSN:1712-9532
1918-1493
DOI:10.1155/2024/4749097